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Neuroimaging of Stroke and Ischemia in Animal Models

机译：动物模型中风和缺血的神经影像学

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Magnetic resonance imaging (MRI) has dramatically changed our ability to diagnose and treat stroke as well as follow its evolution and response to treatment. Early stroke and ischemia can be visualized using diffusion-weighted imaging that utilizes water diffusion within tissues as a reporter for evolving neuropathology that reflects cytotoxic edema, particularly during the first several days after injury. T2-weighted imaging is used for evaluation of vasogenic edema but also is a reliable indicator of the volume and regional distribution of injured tissues. Perfusion-weighted imaging can be used to assess vascular function and also to evaluate potential tissues that might be rescued using therapeutic interventions (core vs. penumbra). Other imaging modalities such as magnetic resonance spectroscopy, diffusion tensor imaging, and susceptibility-weighted imaging are also being used to assist in rapid diagnosis of injured tissues following stroke. While visual analysis of MR data can provide some information about the evolution of injury, quantitative analyses allow definitive and objective evaluations of the injury and could be used to assess novel therapeutic strategies. We review here the basic uses of neuroimaging, focusing on MR approaches to assess stroke and ischemic injury in animal models.
机译：磁共振成像（MRI）极大地改变了我们诊断和治疗中风的能力，并关注其发展和对治疗的反应。早期卒中和缺血可以使用扩散加权成像来可视化，该成像利用组织内的水扩散作为反映细胞毒性水肿的进化神经病理的报告基因，尤其是在损伤后的头几天。 T2加权成像用于评估血管性水肿，但它也是受伤组织的体积和区域分布的可靠指标。灌注加权成像可用于评估血管功能，也可用于评估可通过治疗干预（核心vs半影）挽救的潜在组织。其他成像方式，例如磁共振波谱，扩散张量成像和磁化系数加权成像，也被用于协助中风后受伤组织的快速诊断。虽然MR数据的可视化分析可以提供有关损伤​​演变的一些信息，但是定量分析可以对损伤进行确定性和客观的评估，并且可以用于评估新的治疗策略。我们在这里回顾了神经影像学的基本用途，重点是在动物模型中评估卒中和缺血性损伤的MR方法。

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