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Multimodal MRI of Experimental Stroke

机译：实验性卒中的多模式MRI

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Stroke is the fourth leading cause of death and the leading cause of long-term disability in USA. Brain imaging data from experimental stroke models and stroke patients have shown that there is often a gradual progression of potentially reversible ischemic injury toward infarction. Reestablishing tissue perfusion and/or treating with neuroprotective drugs in a timely fashion are expected to salvage some ischemic tissues. Diffusion-weighted imaging based on magnetic resonance imaging (MRI) in which contrast is based on water motion can detect ischemic injury within minutes after onsets, whereas computed tomography and other imaging modalities fail to detect stroke injury for at least a few hours. Along with quantitative perfusion imaging, the perfusion–diffusion mismatch which approximates the ischemic penumbra could be imaged noninvasively. This review describes recent progresses in the development and application of multimodal MRI and image analysis techniques to study ischemic tissue at risk in experimental stroke in rats.
机译：在美国，中风是第四大死亡原因和长期残疾的主要原因。来自实验性中风模型和中风患者的脑成像数据表明，潜在的可逆性缺血性损伤通常会逐渐发展为梗塞。预期及时重建组织灌注和/或用神经保护药物治疗可以挽救某些缺血性组织。基于磁共振成像（MRI）的扩散加权成像（其中基于水运动的对比度）可以在发病后数分钟内检测出缺血性损伤，而计算机断层扫描和其他成像方式则至少要检测几个小时才能检测出中风损伤。除定量灌注成像外，还可以通过非侵入性方式对近似缺血半影的灌注-扩散失配进行成像。这篇综述描述了多模态MRI和图像分析技术的发展和应用的最新进展，以研究大鼠实验性卒中中处于危险中的缺血组织。

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