Chemokines and Their Receptors in Intracerebral Hemorrhage

Yao Yao; Stella E. Tsirka

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Chemokines and Their Receptors in Intracerebral Hemorrhage

机译：脑出血中的趋化因子及其受体

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Intracerebral hemorrhage (ICH) is a devastating clinical event which results in a high rate of disability and death. At present, no effective treatment is available for ICH. Accumulating evidence suggests that inflammatory responses contribute significantly to the ICH-induced secondary brain outcomes. During ICH, inflammatory cells accumulate at the ICH site attracted by gradients of chemokines. This review summarizes recent progress in ICH studies and the chemoattractants that act during the injury and focuses on and introduces the basic biology of the chemokine monocyte chemoattractant protein-1 (MCP1) and its role in the progression of ICH. Better understanding of MCP1 signaling cascade and the compensation after its inhibition could shed light on the development of effective treatments for ICH.

机译：脑出血（ICH）是一种破坏性的临床事件，导致高比例的残疾和死亡。目前，尚无有效的ICH治疗方法。越来越多的证据表明，炎症反应对ICH诱发的继发性大脑结局具有重要作用。在ICH期间，趋化因子梯度吸引的ICH细胞中会积聚炎症细胞。这篇综述总结了ICH研究和在损伤过程中发挥作用的化学引诱剂的最新进展，重点介绍了趋化因子单核细胞化学引诱蛋白-1（MCP1）的基本生物学及其在ICH进展中的作用。更好地了解MCP1信号级联及其抑制后的补偿可能为ICH的有效治疗方法的开发提供启发。

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来源
《Translational Stroke Research》 |2012年第s1期|70-79|共10页
作者
Yao Yao; Stella E. Tsirka;
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作者单位

Program in Molecular and Cellular Pharmacology Department of Pharmacological Sciences Stony Brook University Stony Brook NY 11794-8651 USA;

Program in Molecular and Cellular Pharmacology Department of Pharmacological Sciences Stony Brook University Stony Brook NY 11794-8651 USA;

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正文语种 eng
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关键词
MCP1; Mouse; Chemokines;

机译：MCP1;小鼠;趋化因子;

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1. Predicting 30-day mortality in patients with primary intracerebral hemorrhage (ICH): Evaluation of the value of intracerebral hemorrhage and modified new intracerebral hemorrhage scores [J] . Farzad Rahmani, Reza Rikhtegar, Alireza Ala, Iranian Journal of Neurology . 2018,第1期

机译：预测原发性脑出血（ICH）患者的30天死亡率：评估脑出血的价值和改良的新脑出血评分
2. Detection of high serum concentration of CXC chemokine ligand-12 in acute intracerebral hemorrhage [J] . Shen Jia, Chen Bin, Zheng Guan-Rong, Clinica chimica acta: International journal of clinical chemistry and applied molecular biology . 2017,第期

机译：检测急性脑内出血中CXC趋化因子配体-12的高血清浓度
3. TLR7 (Toll-Like Receptor 7) Facilitates Heme Scavenging Through the BTK (Bruton Tyrosine Kinase)-CRT (Calreticulin)-LRP1 (Low-Density Lipoprotein Receptor-Related Protein-1)-Hx (Hemopexin) Pathway in Murine Intracerebral Hemorrhage [J] . Wang Gaiqing, Guo Zhenni, Tong Lusha, Stroke: A Journal of Cerebral Circulation . 2018,第12期

机译：TLR7（Toll样受体7）利用血红素清除通过BTK（Bruton Tyrosine激酶）-crt（CaltreteLin）-crt（CaltriteLin）-LRP1（低密度脂蛋白受体相关蛋白-1）-HX（血红蛋白）途径鼠脑内出血
4. Polymorphisms of chemokine and chemokine receptor genes in Alzheimer's and Parkinson's Patients [C] . Reale M., GattaV., Di Nicola M., International Conference on Alzheimer's and Parkinson's Diseases . 2009

机译：阿尔茨海默氏症和帕金森患者中趋化因子和趋化因子受体基因的多态性
5. Trans-Ethnic Meta-Analysis of Vitamin D Receptor Gene Variants in Context of Polygenic Risk, Associated with Difference in Incidence of Hypertension-Mediated Intracerebral Hemorrhage Across Ethnic Groups [D] . Henry, Jonathan. 2021

机译：维生素D受体基因变体的反族荟萃分析在多基因风险背景下，与族群中血管介导的脑出血发生率的差异相关
6. Predicting 30-day mortality in patients with primary intracerebral hemorrhage: Evaluation of the value of intracerebral hemorrhage and modified new intracerebral hemorrhage scores [O] . Farzad Rahmani, Reza Rikhtegar, Alireza Ala, 2018

机译：预测原发性脑出血患者的30天死亡率：评估脑出血的价值和改良的新脑出血评分
7. SAT-544 Primary Aldosteronism in Intracerebral Hemorrhage. Not Intracerebral Hemorrhage in Primary Aldosteronism [O] . Makoto Arai, Katsunari Kiko, Takanori Suzuki, 2020

机译：SAT-544脑出血中的原代醛固酮。不是原发性醛固酮的脑出血

Chemokines and Their Receptors in Intracerebral Hemorrhage

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