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首页> 外文期刊>Translational Stroke Research >Granulocyte-colony-stimulating Factor for Acute Ischemic Stroke: A Randomized Controlled Trial (STEMTHER)
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Granulocyte-colony-stimulating Factor for Acute Ischemic Stroke: A Randomized Controlled Trial (STEMTHER)

机译：急性缺血性卒中的粒细胞集落刺激因子：随机对照试验（STEMTHER）

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摘要

Granulocyte-colony-stimulating factor (G-CSF) functions both as a neuroprotectant and a stimulator of autologous bone marrow stem cell release. Therefore, administration of G-CSF should improve the outcome of stroke. Here, we examine the safety of using G-CSF to treat acute ischemic stroke using a randomized controlled trial involving 20 adult patients presenting with ischemia in the carotid region within 48 h of onset. The experimental group (n = 10) received subcutaneous G-CSF injections (10 mg kg?1 day?1) in addition to conventional therapy for 5 days. The primary outcome was motor function as measured by the modified Rankin Scale 180 days post-stroke. Safety was evaluated according to the frequency of hemorrhagic transformation of infarctions and serious adverse events. Only six patients in the experimental group completed full course of treatment, while four patients (three in the control and one in the experimental group) were lost to follow-up. We found the experimental and control groups did not differ significantly in either neurological impairment or degree of disability/dependence at 180 days post-stroke. We conclude that while adding G-CSF (10 mg kg?1 day?1) to acute ischemic stroke therapy for 5 days is safe, its efficacy remains unproven.
机译：粒细胞集落刺激因子（G-CSF）既作为神经保护剂，又作为自体骨髓干细胞释放的刺激物。因此，服用G-CSF应该改善中风的预后。在这里，我们通过一项随机对照试验，研究了使用G-CSF治疗急性缺血性中风的安全性，该试验涉及20名在发病48小时内在颈动脉区域出现缺血的成年患者。除常规治疗外，实验组（n = 10）还接受了皮下G-CSF注射（10 mg kg？1 天？1 ），为期5天。主要结果是运动功能，如中风后180天通过改良的Rankin量表测得。根据梗死的出血性转化频率和严重不良事件评估安全性。实验组中只有六名患者完成了整个疗程，而四名患者（对照组中三名，实验组中一名）失去了随访。我们发现实验组和对照组在中风后180天的神经功能障碍或残疾/依赖性程度上均无显着差异。我们得出的结论是，在急性缺血性中风治疗中加入G-CSF（10 mg kg？1 天？1 ）5天是安全的，但其疗效尚未得到证实。

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