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首页> 外文期刊>Translational Stroke Research >Neural Stem Cell-Based Therapy for Ischemic Stroke
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Neural Stem Cell-Based Therapy for Ischemic Stroke

机译：基于神经干细胞的缺血性卒中治疗

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Stem cell-based approaches for the treatment of stroke have been the subject of intensive research over the past decade. Based on accumulated experimental evidence, stem cell-based therapy is a very promising prospect for the development of a novel treatment to restore stroke-damaged brain and impaired neurological function. Studies performed on experimental animal models of stroke employed a variety of stem cell types from diverse sources and have demonstrated their ability to replace lost neurons and functionally integrate into the brain, modulate inflammation, and stimulate angiogenesis and neurogenesis from an endogenous stem cell pool, most likely through trophic actions. A few clinical trials in stroke patients using stem cell transplantation have been completed or are on-going but the results have not yet proven the effectiveness of the stem cell-based approaches. A joint effort of stroke researchers and clinicians is needed to further optimize treatment protocols using safe and reproducible stem cell sources tested in relevant animal models of stroke and showing substantial neurological recovery of stroke-impaired function.
机译：在过去十年中，以干细胞为基础的中风治疗方法一直是深入研究的主题。基于积累的实验证据，基于干细胞的疗法对于开发一种新的疗法来恢复中风损伤的脑部和神经功能受损的疗法具有非常广阔的前景。对中风的实验动物模型进行的研究使用了来自多种来源的多种干细胞类型，并证明了它们具有替代内源性干细胞池中失去的神经元并功能整合至大脑，调节炎症，刺激血管生成和神经发生的能力。可能是通过营养行动。使用干细胞移植的中风患者的一些临床试验已经完成或正在进行中，但结果尚未证明基于干细胞的方法的有效性。中风研究人员和临床医生需要共同努力，以使用在相关中风动物模型中测试的安全且可复制的干细胞来源进一步优化治疗方案，并显示中风受损功能的实质性神经恢复。

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