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Surpassing nature:rational design of sterile-surface materials

机译:超越自然:无菌表面材料的合理设计

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摘要

The rise of multidrug-resistant pathogens and recalcitrance of biofilm infections present a formidable challenge to combating infectious diseases.There are numerous disinfectants and antiseptics for treating materials in hospitals and community settings,and devices such as catheters impregnated with anti-infectives have been introduced into practice.However,there are many limitations of materials impregnated with a leaching antibacterial agent.Recently,non-leaching,permanent,sterile-surface materials have been developed in which one end of a long-chained hydrophobic polycation containing antimicrobial monomers is attached covalently to the surface of a material,for example,cotton or plastic.The polymeric chain allows the antimicrobial moieties to permeate into,and kill,the cells of the pathogen.These sterile-surface materials kill both air-and waterborne pathogens and are not susceptible to existing resistance mechanisms.
机译:耐多药病原体的出现和生物膜感染的顽固性是与传染病作斗争的巨大挑战。医院和社区中有许多用于处理材料的消毒剂和防腐剂,并且已经引入了诸如浸渍有抗感染剂的导管之类的设备。然而,浸提抗菌剂浸渍的材料有很多局限性。最近,已经开发出非浸提,永久性,无菌表面材料,其中长链疏水性聚阳离子抗菌单体的一端共价连接到聚合物链可以使抗菌部分渗透并杀死病原体的细胞。这些无菌表面材料可以杀死空气和水传播的病原体,并且不易感染现有的抵抗机制。

著录项

  • 来源
    《Trends in Biotechnology》 |2005年第7期|p.343-348|共6页
  • 作者单位

    Department of Biology,Northeastern University,360 Huntington Ave,Boston,MA 02115,USA;

    Department of Chemistry and Division of Biological Engineering,Massachusetts Institute of Technology,Cambridge,MA 02139,USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
  • 关键词

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