A new science-business paradigm in anticancer drug development.

Blagosklonny MV

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A new science-business paradigm in anticancer drug development.

机译：抗癌药物开发的新的科学商业范式。

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Studies into the molecular mechanisms of cancer have revealed that, with a few exceptions, the disease lacks a specific drug target. Therefore, new anticancer drugs not only take many years and much money to develop but also might not outperform existing drugs. However, what are assumed to be unfavorable hallmarks of cancer, for example drug resistance, can be exploited for selective anticancer therapy and for protection of normal cells. Based on this paradigm, the drug discovery can be complemented by novel use of existing agents and even 'failed' drugs. The pharmacological industry could develop low cost, effective therapeutic modalities, by 're-using' already marketed and late-stage products in cancer-selective therapeutic kits.

机译：对癌症分子机制的研究表明，除少数例外，该疾病缺乏特定的药物靶标。因此，新的抗癌药不仅需要花费大量的时间和金钱来开发，而且可能不会比现有的药物表现更好。但是，可以将被认为是不利的癌症标志（例如耐药性）用于选择性抗癌治疗和保护正常细胞。基于这种范例，可以通过新颖使用现有药物甚至“失败的”药物来补充药物发现。药理学行业可以通过在癌症选择性治疗试剂盒中“重用”已经上市和后期的产品来开发低成本，有效的治疗方式。

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来源
《Trends in Biotechnology》 |2003年第3期|P.103-106|共4页
作者
Blagosklonny MV;
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作者单位

Brander Cancer Research Institute, Dept of Medicine, New York Medical College, 19 Bradhurst Ave, 10532, Hawthorne, NY, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种 eng
中图分类分子生物学;生物工程学（生物技术）;生物科学的研究方法与技术;普通生物学;
关键词
paradigm; Malignant Neoplasms; drug development; Therapeutic; drug discovery;

机译：范例;恶性肿瘤;药物开发;治疗;药物发现;

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1. Tumor physiology and charge dynamics of anticancer drugs: implications for camptothecin-based drug development. [J] . Adams DJ, Morgan LR Current medicinal chemistry . 2011,第9期

机译：肿瘤生理学和抗癌药的电荷动力学：对基于喜树碱的药物开发的影响。
2. Drug-induced QTc interval prolongation: A proposal towards an efficient and safe anticancer drug development. [J] . Curigliano G, Spitaleri G, Fingert HJ, European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2008,第4期

机译：药物诱导的QTc间隔时间延长：朝着有效和安全的抗癌药物开发的建议。
3. Open source drug discovery- A new paradigm of collaborative research in tuberculosis drug development. [J] . Brahmachari SK Tuberculosis . 2011,第5期

机译：开源药物发现-结核药物开发中合作研究的新范例。
4. EFFECT OF DRUG LOADING IN ANTICANCER POLYMER-DRUG CONJUGATE ON INTERACTIONS WITH CELLS AND ENZYMATIC RELEASE OF DRUG [C] . R. Prakash, V. Omelyanenko, C. Anderson, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：抗癌药-药物共轭物中药物负荷对细胞相互作用和药物酶释放的影响
5. High-resolution NMR spectroscopic analysis of anticancer drugs, DNA and their interactions: 1. Platinum anticancer compounds - DNA interactions. 2. Anthracycline drugs - DNA interactions and modified DNA. [D] . Yang, Danzhou. 1996

机译：抗癌药物，DNA及其相互作用的高分辨率NMR光谱分析：1.铂类抗癌化合物-DNA相互作用。 2.蒽环类药物-DNA相互作用和修饰的DNA。
6. Transcription factor-based drug design in anticancer drug development. [O] . A. G. Papavassiliou 1997

机译：抗转录药物开发中基于转录因子的药物设计。
7. A 3D fibrous scaffold inducing tumoroids: a platform for anticancer drug development. [O] . Yvonne K Girard, Chunyan Wang, Sowndharya Ravi, 2013

机译：诱导肿瘤的3D纤维支架：抗癌药物开发的平台。

A new science-business paradigm in anticancer drug development.

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