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首页> 外文期刊>Tropical Animal Health and Production >Performance evaluation of two serological tests for contagious bovine pleuropneumonia (CBPP) detection in an enzootic area using a Bayesian framework
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Performance evaluation of two serological tests for contagious bovine pleuropneumonia (CBPP) detection in an enzootic area using a Bayesian framework

机译：使用贝叶斯框架的两个血清学检测在牛传染性胸膜肺炎（CBPP）检测中的性能评估

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摘要

A Bayesian approach, allowing for conditional dependence between two tests was used to estimate without gold standard the sensitivities of complement fixation test (CFT) and competitive enzyme-linked immunosorbent assay test (cELISA) and the serological prevalence of CBPP in a cattle population of the Central Delta of the Niger River in Mali, where CBPP is enzootic and the true prevalence and animals serological state were unknown. A significant difference (P = 0.99) was observed between the sensitivities of the two tests, estimated at 73.7% (95% probability interval [PI], 63.4–82.7) for cELISA and 42.3% (95% PI, 33.3–53.7) for CFT. Individual-level serological prevalence in the study population was estimated at 14.1% (95% PI, 10.8–16.9). Our results indicate that in enzootic areas, cELISA performs better in terms of sensitivity than CFT. However, negative conditional sensitivity dependence between the two tests was detected, implying that to achieve maximum sensitivity, the two tests should be applied in parallel.
机译：在没有金标准的情况下，使用允许在两个测试之间有条件依赖性的贝叶斯方法来估计补体固定测试（CFT）和竞争性酶联免疫吸附测定（cELISA）的敏感性以及CBPP在该牛群中的血清学流行率。马里尼日尔河的中部三角洲，CBPP在这里是动物生境，真正的流行率和动物血清状况尚不清楚。两种测试的敏感性之间存在显着差异（P = 0.99），据估计cELISA的灵敏度为73.7％（95％概率区间[PI]，63.4-82.7），而4ELISA的灵敏度为42.3％（95％PI，33.3-53.7）。 CFT。在研究人群中个体水平的血清学流行率估计为14.1％（95％PI，10.8-16.9）。我们的结果表明，在动物检疫区，cELISA的敏感性优于CFT。但是，在两个测试之间检测到负的条件灵敏度依赖性，这意味着要实现最大灵敏度，应并行应用两个测试。

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