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首页> 外文期刊>Ultrasound >Sonographic Characterisation of Tissue Changes Associated with Infused Apomorphine Hydrochloride: A Case Series
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Sonographic Characterisation of Tissue Changes Associated with Infused Apomorphine Hydrochloride: A Case Series

机译：超声频谱特征与输注盐酸阿扑吗啡相关的组织变化：一个病例系列

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Apomorphine hydrochloride is used to treat refractory motor fluctuations in advanced Parkinson's disease. Delivery by infusion is associated with the formation of hard subcutaneous nodules, which may be painful, limit available infusion sites, and interfere with absorption of the drug. Diagnostic ultrasound was used to image affected tissue in 12 people experiencing apomorphine nodule formations. It revealed significant departures from normality in dermal and subcutaneous tissue, including a variety of nodule appearances, dermal thickening and diffuse changes consistent with inflammatory reactions. Sonographic appearances differed markedly between individuals, but no clear correlation between severity of tissue changes, patient demographics and apomorphine dose was observed. Diagnostic ultrasound may be useful as a non-invasive method of assessing subcutaneous nodule formation, to measure changes in affected tissue over time and after treatment.
机译：盐酸阿扑吗啡用于治疗晚期帕金森氏病的难治性运动波动。通过输注递送与硬皮下结节的形成有关，这可能是痛苦的，限制了可用的输注部位，并干扰了药物的吸收。诊断超声被用于为12位经历阿扑吗啡小结形成的人的受累组织成像。它显示出真皮和皮下组织的正常状态有明显的偏离，包括各种结节外观，真皮增厚以及与炎症反应一致的弥漫性变化。个体之间的超声检查表现明显不同，但是在组织变化的严重程度，患者人口统计学和阿扑吗啡剂量之间没有明显的相关性。诊断超声可以用作评估皮下结节形成的非侵入性方法，以测量受累组织随时间和治疗后的变化。

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