Interference Leads to Cancer Growth

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Interference Leads to Cancer Growth

机译：干扰导致癌症生长

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Overactivity of a protein that normally cues cells to divide sabotages the body's natural cellular recycling process, leading to heightened can- cer growth and chemotherapy resistance, researchers at the University of Texas Southwestern Medical Center, Dallas, have found. The epidermal growth factor receptor, or EGFR, is found at abnormally high levels on the surface of many types of cancer cells. The study, led by Beth Levine, director of the Center for Autophagy Research and a Howard Hughes Medical Institute investigator, revealed that EGFR turns off autophagy, a process by which cells recycle unneeded parts, by binding to a protein, Beclin 1, which normally turns on the process. The deactivation of autophagy by EGFR leads to more rapid tumor growth and chemotherapy resistance.

机译：德克萨斯大学西南医学中心的研究人员发现，通常会提示细胞分裂的一种蛋白质，其过度活跃会破坏人体自然的细胞循环过程，从而导致癌症生长和化疗耐药性增强。在许多类型的癌细胞表面上发现表皮生长因子受体或EGFR异常高水平。该研究由自噬研究中心主任和霍华德·休斯医学研究所的研究员贝丝·莱文（Beth Levine）领导，该研究表明，EGFR通过与蛋白质Beclin 1结合而关闭自噬，自噬是细胞回收不需要的部分的过程。打开过程。 EGFR使自噬失活会导致更快的肿瘤生长和化疗耐药性。

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《USA today》 |2015年第2837期|13-14|共2页
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1. Inhibiting tumor growth of colorectal cancer by blocking the expression of vascular endothelial growth factor receptor 3 using interference vector-based RNA interference [J] . LuiZhicheng, MaQiang, WangXianghui, International journal of molecular medicine . 2010,第1期

机译：通过基于干扰载体的RNA干扰，通过阻断血管内皮生长因子受体3的表达来抑制大肠癌的肿瘤生长
2. Inhibiting tumor growth of colorectal cancer by blocking the expression of vascular endothelial growth factor receptor 3 using interference vector-based RNA interference. [J] . Lui Z, Ma Q, Wang X, International journal of molecular medicine . 2010,第1期

机译：通过使用基于干扰载体的RNA干扰阻断血管内皮生长因子受体3的表达，从而抑制大肠癌的肿瘤生长。
3. Predicting recurrence in non-muscle invasive bladder cancer following instillation of chemotherapy: Interference with transcription factor TFAP2a leads to a decrease in chemosensitivity in bladder cancer [J] . Xie Yu, Fan Gang, Liu Chun, International journal of molecular medicine . 2015,第Suppla1期

机译：滴注化疗后预测非肌肉浸润性膀胱癌的复发：干扰转录因子TFAP2a会导致膀胱癌的化学敏感性降低
4. Silencing of the Fatty Acid Synthase Gene by RNA Interference Inhibits Growth and Induces Apoptosis of LNCaP Prostate Cancer Cells [C] . Ellen De Schrijver, Koen Brusselmans, Walter Heyns, International Symposium on Hormonal Carcinogenesis . 2005

机译：通过RNA干扰沉默脂肪酸合成酶基因抑制生长并诱导LNCAP前列腺癌细胞的凋亡
5. Endangered plant species for potential drug leads and anticancer prototypes for treatment of breast and pancreatic cancers. [D] . Oh, Joonseok. 2015

机译：濒临灭绝的植物物种，可能用于治疗乳腺癌和胰腺癌的潜在药物线索和抗癌原型。
6. Interference with Activator Protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells [O] . Verena Thewes, Francesca Orso, Richard Jäger, 2010

机译：干扰激活蛋白2转录因子可诱导乳腺癌细胞凋亡并增加其化学敏感性和放射敏感性
7. Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice [O] . Laura N Burga, Hai Hu, Ashish Juvekar, 2011

机译：BRCA1的缺失导致乳腺上皮细胞中表皮生长因子受体的表达增加，而表皮生长因子受体的抑制可防止BRCA1突变小鼠中雌激素受体阴性的癌症
8. Investigation of the Growth of Lead Magnesium Niobate - and Lead Zinc Niobate - Lead Titanate Solid Solution Single Crystals by the Bridgeman Technique [R] . Feigelson, R. S. 2002

机译：用Bridgeman技术研究铌酸铅镁和铅铌酸铅 - 钛酸铅固溶体单晶的生长

Interference Leads to Cancer Growth

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