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首页> 外文期刊>Wiener klinische Wochenschrift >LDL-Cholesterin in der Sekund?rpr?vention: Zielwert-Erreichung unter Lipidsenkern in Praxis und Spital in ?sterreich (ZIEL)
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LDL-Cholesterin in der Sekund?rpr?vention: Zielwert-Erreichung unter Lipidsenkern in Praxis und Spital in ?sterreich (ZIEL)

机译：LDL胆固醇的二级预防：在奥地利的实践中和医院中降脂患者的目标实现目标（TARGET）

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BACKGROUND: A hospital-based screening project (HSP) in Austria found 47% of high-risk patients (LDL-C < 100 mg/dl) and 24% of very high-risk patients (LDL-C < 70 mg/dl) at goal. Separate data for the sexes were not reported. We analyze whether LDL-C goal attainment in patients with manifest atherosclerosis and/or diabetes on stable lipid-lowering treatment differs between private practice and hospital and between men and women. PATIENTS AND METHODS: From September to November 2007, 49 Austrian centers (36 private practice, 13 hospitals) documented vascular morbidity, lipid levels, and lipid lowering treatment in patients with high risk (atherosclerosis or diabetes, n = 978) and very high risk (coronary heart disease and diabetes or acute coronary syndrome, n = 322). RESULTS: 75% and 25% of the 1300 patients were high and very high risk, respectively. LDL-C goals of < 100 and < 70 mg/dl, respectively, were attained by 45.4% and 26.4% of patients (p < 0.001). A similar percentage of patients with very high risk was found in men and women (26.4% vs. 22.9%, NS) and goal attainment was not influenced by sex (high risk: 47.2% (m) vs. 43.8% (w), NS and very high risk: 29.1% (m) vs. 22.4% (w), NS). In patients with high risk, 41.6% treated in private practice vs. 57.9% treated in the hospital were at goal (p < 0.001). In patients with very high risk, 15.9% treated in private practice vs. 45.2% treated in the hospital were at goal (p < 0.001). Lower goal-attainment in private practice occurred despite significantly more intensive lipid intervention and probably reflects higher baseline LDL-C. LDL-C > 100 mg/dl leads to a more aggressive lipid lowering in approx. 70% of patients, irrespective of whether they are treated in private practice or in the hospital. LDL-C between 70 and 100 mg/dl, however, leads to a more aggressive lipid lowering in < 5% of patients, irrespective of whether they are high or very high risk. CONCLUSION: As observed in EUROASPIRE III for other European countries, there is substantial potential for improvement in lipid control in Austrian cardiovascular high-risk patients, irrespective of whether they are treated in private practice or in the hospital.
机译：背景：奥地利的医院筛查项目（HSP）发现47％的高危患者（LDL-C <100 mg / dl）和24％的高危患者（LDL-C <70 mg / dl）在目标。未报告性别的单独数据。我们分析了在私人诊所和医院之间以及在男女之间，在稳定的降脂治疗中，患有明显动脉粥样硬化和/或糖尿病的患者的LDL-C目标达成情况是否存在差异。患者与方法：从2007年9月至11月，奥地利的49个中心（36个私人诊所，13家医院）记录了高风险（动脉粥样硬化或糖尿病，n = 978）和极高风险患者的血管发病率，血脂水平和降脂治疗（冠心病和糖尿病或急性冠状动脉综合征，n = 322）。结果：1300名患者中分别有75％和25％为高风险。患者的LDL-C目标分别<100和<70 mg / dl，分别达到45.4％和26.4％（p <0.001）。男性和女性的高风险患者比例相似（26.4％vs. 22.9％，NS），而目标实现不受性别的影响（高风险：47.2％（m）对43.8％（w）， NS和极高风险：29.1％（m）对22.4％（w），NS）。在高危患者中，以私人执业方式治疗的比例为41.6％，而在医院中为57.9％（p <0.001）。在极高风险患者中，以私人执业治疗为15.9％，而在医院治疗为45.2％为目标（p <0.001）。尽管明显加强了脂质干预，但私人执业的目标达成率仍然较低，并且可能反映了较高的基线LDL-C。 LDL-C> 100 mg / dl会导致脂质的侵略性降低，降低幅度约为100 mg / dl。 70％的患者，无论是在私人诊所还是在医院接受治疗。然而，LDL-C在70至100 mg / dl之间会导致<5％的患者发生更具侵略性的脂质降低，无论其高风险还是极高风险。结论：正如在EUROASPIRE III中针对其他欧洲国家所观察到的那样，无论是在私人诊所还是在医院治疗，奥地利心血管高危患者的脂质控制都有很大的改善潜力。

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