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Imaging system simplifies pathological evaluations

机译：成像系统简化了病理评估

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To determine the most appropriate treatment for diseases such as cancer, researchers must study individual cells and tissues. Their analysis relies on hundreds of immunohisto-chemical (tissue-based) and immunocytochemical (cell-based) tests, which involve staining samples with commercially avail-able reagents and observing the sample's chemical reaction un-der a microscope. Several automated imaging systems for cellular analysis are currently available for specific pathological and drug-discovery assays; however, the PC host and microscope combination system, Automated Cellular Imaging System (ACIS), from ChromaVision Medical Systems (San Juan Capistrano, CA; www.chomomavi-sion.com) provides a single platform for the evaluations. The ACIS uses a custom-made, bright-field microscope that can accommodate any standard microscope objective as a result of an automated motorized light condenser controlled by a proprietary light-controller board in the PC host. The condenser adjusts the light path and levels based on the needs of the specific assay. This versatility is critical to ACIS operation because, after a tray of 100 slides is loaded into a robotic conveyor system, the ACIS takes a series of images with progressively higher magnification to automatically identify cells that exhibit certain user-set characteristics such as color, intensity, and shape.
机译：为了确定最适合癌症等疾病的治疗方法，研究人员必须研究单个细胞和组织。他们的分析依赖于数百种免疫组织化学（基于组织）和免疫细胞化学（基于细胞）的测试，其中包括用市售试剂对样品进行染色，并在显微镜下观察样品的化学反应。目前有几种用于细胞分析的自动化成像系统可用于特定的病理学和药物发现分析；但是，来自ChromaVision Medical Systems（加利福尼亚州圣胡安·卡皮斯特兰诺； www.chomomavi-sion.com）的PC主机和显微镜组合系统，自动细胞成像系统（ACIS）提供了一个评估平台。 ACIS使用定制的明视野显微镜，由于PC主机中的专有光控制板控制着自动电动聚光器，因此可以容纳任何标准显微镜物镜。聚光器根据特定测定的需要调整光路和水平。这种多功能性对于ACIS操作至关重要，因为在将100张载玻片托盘装入自动传送系统后，ACIS会以一系列放大倍数逐渐放大的图像来自动识别具有某些用户设置特征（例如颜色，强度）的细胞和形状。

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