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首页> 外文期刊>Journal of Virology >Comparison of In Vitro and Cell-Mediated Alteration of a Human Rhinovirus and Its Inhibition by Sodium Dodecyl Sulfate
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Comparison of In Vitro and Cell-Mediated Alteration of a Human Rhinovirus and Its Inhibition by Sodium Dodecyl Sulfate

机译：体外和细胞介导的人鼻病毒改变的比较及其硫酸钠抑制作用

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After human rhinovirus type 2 (HRV-2) attaches to HeLa cells, two types of subviral particles are formed which closely resemble particles produced in vitro by acid or heat. One type of particle contains RNA whereas the second sediments as an empty capsid and is RNA-deficient. Sodium dodecyl sulfate (SDS) at 10?4 M inhibits the cell-mediated formation of these particles from HRV-2 virions and the ability of HRV-2 to form plaques, but it does not inhibit the formation of plaques by human rhinovirus 14 (HRV-14). SDS also stabilizes HRV-2 against inactivation by acid or heat to a much greater extent than it does HRV-14. In a similar manner, SDS protects against the acid inactivation of the subpopulation of HRV-2 natural top component particles which attach to virus-specific cellular receptors. This suggests that the loss of native properties of natural top component particles and of virion are related processes. The basis for this alteration and also its role in infection are discussed.
机译：在人鼻病毒2（HRV-2）附着于Hela细胞后，形成两种类型的亚亚病颗粒，其与酸或热量的体外非常类似的颗粒。一种类型的颗粒含有RNA，而第二沉积物作为空衣壳，并且是RNA缺陷的。十二烷基硫酸钠（SDS）在10 β4 m抑制细胞介导的这些颗粒的形成，以及HRV-2形成斑块的能力，但它不会抑制形成人类鼻病毒14的斑块（HRV-14）。 SDS还稳定HRV-2对酸或热量的灭活，比HRV-14更大程度地更大。以类似的方式，SDS保护酸灭活HRV-2天然顶部组分颗粒的亚沉积，其附着于病毒特异性细胞受体。这表明天然顶部组分颗粒和病毒粒子的天然性质的丧失是相关的过程。讨论了这种改变的基础以及其在感染中的作用。

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