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首页> 外文期刊>The biochemical journal >The significance of changes in tissue clearing-factor lipase activity in relation to the lipaemia of pregnancy
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The significance of changes in tissue clearing-factor lipase activity in relation to the lipaemia of pregnancy

机译：组织清除因子脂肪酶活性变化与妊娠期脂质血症相关的重要性

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p1. The concentration of triglyceride fatty acid in the plasma of the pregnant rat rises to a maximum 2–4 days before parturition. Thereafter there is a rapid decline in the concentration to near normal values at parturition. 2. A similar increase occurs in animals fed on a diet low in fat. There is no increase in food consumption at the time when the triglyceride fatty acid concentration in the plasma is at its peak. 3. Rates of entry of triglyceride fatty acid into the blood during pregnancy have been estimated from the rate of accumulation of triglyceride in the plasma of animals injected with a non-ionic detergent, Triton. A progressive increase occurs in the entry rate as the body weight increases throughout pregnancy. Expressed per constant body weight, the entry rate does not change significantly. 4. Adipose-tissue clearing-factor lipase activity is low at the time when the plasma triglyceride fatty acid concentration is raised. Activity of the enzyme in heart, lung and diaphragm is unchanged. 5. It is suggested that the ‘lipaemia of pregnancy’ may be due to diminished uptake of triglyceride fatty acids by adipose tissue, and, further, that the disappearance of the lipaemia may be due to increased uptake of triglyceride fatty acids by the mammary gland./p
机译：> 1。在孕鼠血浆中甘油三酯脂肪酸的浓度在分娩前升高到最多2-4天。之后，浓度迅速下降到分娩的正常值。 2.在脂肪饮食中喂养的动物中发生类似的增加。在血浆中甘油三酯脂肪酸浓度在其峰值时，食物消耗不会增加。 3.从甘油三酯中甘油三酯的血浆中注入非离子洗涤剂的血浆中，甘油三酯脂肪酸进入血液中的甘油三酯脂肪酸进入血液的速率。随着体重在整个怀孕期间增加，进入率发生逐渐增加。每恒定体重表示，入口率不会显着变化。 4.脂肪组织清除因子脂肪酶活性在升高等离子体甘油三酯脂肪酸浓度时低于升高。心脏，肺和隔膜中酶的活性不变。有人建议，“妊娠的脂质血症”可能是由于脂肪组织减少了甘油三酯脂肪酸的摄取，并且进一步，脂肪血症的消失可能是由于乳腺甘油三酯脂肪酸的摄取增加。

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