Temperature-sensitive Mutants of Respiratory Syncytial Virus

Meera A. Gharpure; Peter F. Wright; Robert M. Chanock

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Temperature-sensitive Mutants of Respiratory Syncytial Virus

机译：呼吸道合胞病毒的温度敏感突变体

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Four conditional-lethal temperature-sensitive mutants of RS virus were detected among the progeny of 454 plaques derived from virus grown in the presence of 10?4m 5-fluorouridine. These mutants were stable (reversion frequency, 10?5.0 or less and failed to produce plaques at 38 or 39 C. Plaquing efficiency was depressed 100-fold or more at 37 C. Variable suppression of growth at the restrictive temperature of 39 C was observed, ranging from 16-fold to complete suppression. The temperature-sensitive defect of three of the mutants appeared to affect functions which were expressed late in the replicative cycle. One of the mutants produced atypical nonsyncytial plaques.

机译：在10 4℃5-氟氨氨酸存在下生长的病毒生长的454个斑块的后代，检测到RS病毒的四个条件 - 致死的温度敏感突变体。这些突变体是稳定的（逆转频率，10 5.0 或更少，并且未在38或39℃下产生噬斑，在37℃下抑制100倍或更高。在37℃下抑制生长观察到39℃的限制性温度，从16倍到完全抑制。三个突变体的温度敏感缺陷似乎影响复制循环晚期表达的功能。其中一个突变体产生了非典型的非合成斑块。

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《Journal of Virology》 |1969年第4期|共8页
作者
Meera A. Gharpure; Peter F. Wright; Robert M. Chanock;
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收录信息美国《科学引文索引》(SCI);
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1. Respiratory syncytial virus infection in owl monkeys: viral shedding, immunological response, and associated illness caused by wild-type virus and two temperature-sensitive mutants. [J] . G A Prince, S C Suffin, D A Prevar, Infection and immunity . 1979,第3期

机译：猫头鹰猴呼吸道合胞病毒感染：由野生型病毒和两个温度敏感性突变体引起的病毒脱落，免疫反应和相关疾病。
2. Seven complementation groups of respiratory syncytial virus temperature-sensitive mutants. [J] . H B Gimenez, C R Pringle Journal of Virology . 1978,第3期

机译：七种辅导合胞病毒温度敏感突变体的七种互补组。
3. Seven complementation groups of respiratory syncytial virus temperature-sensitive mutants. [J] . H B Gimenez, C R Pringle Journal of Virology . 1978,第3期

机译：七种辅导合胞病毒温度敏感突变体的七种互补组。
4. CHARACTERIZATION OF THE EPITOPE FOR ANTI HUMAN RESPIRATORY SYNCYTIAL VIRUS F PROTEIN MONOCLONAL ANTIBODY 101F USING SYNTHETIC PEPTIDES AND RECOMBINANT F PROTEIN MUTANTS [C] . Marian Kruszynski, Sheng Jiun Wu, Albert Schmidt the European Peptide Symposium . 2007

机译：用合成肽和重组F蛋白突变体表征抗人呼吸道合胞病毒F蛋白单克隆抗体101f的表位
5. Immunopathogenesis of bovine respiratory syncytial virus and acute bovine viral diarrhea virus infections in calves [D] . Brodersen, Bruce Wesley. 1996

机译：牛犊牛呼吸道合胞病毒和急性牛病毒性腹泻病毒感染的免疫发病机制
6. Respiratory syncytial virus infection in owl monkeys: viral shedding immunological response and associated illness caused by wild-type virus and two temperature-sensitive mutants. [O] . G A Prince, S C Suffin, D A Prevar, 1979

机译：猫头鹰猴呼吸道合胞病毒感染：由野生型病毒和两个温度敏感性突变体引起的病毒脱落免疫反应和相关疾病。
7. Clustered Charge-to-Alanine Mutagenesis of Human Respiratory Syncytial Virus L Polymerase Generates Temperature-Sensitive Viruses [O] . Tang Roderick S., Nguyen Nick, Zhou Helen, 2002

机译：人类呼吸道合胞病毒L聚合酶的聚类电荷到丙氨酸诱变产生温度敏感病毒。
8. Development of Attenuated Mutants of Respiratory Syncytial Virus and Parainfluenza Viruses as Potential Vaccine Strains [R] . Simpson, R. W. 1979

机译：作为潜在疫苗株的呼吸道合胞病毒和副流感病毒减毒突变体的研制

Temperature-sensitive Mutants of Respiratory Syncytial Virus

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