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首页> 外文期刊>Journal of Virology >Ultrastructural Study of Long-Term Measles Infection in Cultures of Hamster Dorsal-Root Ganglion
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Ultrastructural Study of Long-Term Measles Infection in Cultures of Hamster Dorsal-Root Ganglion

机译：仓鼠背根神经节培养中长期麻疹感染的超微结构研究

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摘要

The morphogenesis of the Edmonston strain of measles is described in cultures of hamster dorsal-root ganglion maintained for as long as 63 days postinoculation. The patterns observed confirmed those previously reported in both neural and non-neural tissue. However, in the present tissue, the development of viral material could be followed chronologically within different cell types such as neurons and Schwann cells. Active replication was visualized up to 63 days postinoculation. The appearance of cytoplasmic nucleocapsid preceded that of intranuclear nucleocapsid, the latter occurring after 14 days. These intranuclear inclusions were formed after the transformation of the nucleoli into bizarre pleomorphic bodies which eventually segregated into clumps of nucleocapsid. These intranuclear inclusions mimic those seen in subacute sclerosing panencephalitis, now known to be etiologically related to a measles-like virus.
机译：在仓鼠背根神经节的培养物中描述了长达63天的后似梗塞的培养物中edmonston麻疹菌的形态发生。观察到的模式证实了先前在神经和非神经组织中报道的那些。然而，在本组织中，可以在不同细胞类型（如神经元和Schwann细胞）中按顺从遵循病毒材料的发展。活动复制最多可视于63天的时间划分。细胞质核衣壳的出现前面是核核衣壳，后者在14天后发生。在将核仁转化到奇异的茂物体之后形成这些核核夹杂物，其最终将最终分离成核衣壳的丛。这些核心内夹杂物模拟了在亚急性硬化脑膜炎中观察的那些，现在已知在病因上与类似麻疹的病毒有关。

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