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首页> 外文期刊>Journal of Virology >Effect of Rifamycins and Related Antibiotics on the Deoxyribonucleic Acid-Dependent Ribonucleic Acid Polymerase of Vaccinia Virus Particles
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Effect of Rifamycins and Related Antibiotics on the Deoxyribonucleic Acid-Dependent Ribonucleic Acid Polymerase of Vaccinia Virus Particles

机译：利福霉素及相关抗生素对幼虫病毒颗粒脱氧核酸依核核核酸聚合酶的影响

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摘要

A number of compounds related to rifampin which act as expected in the Escherichia coli system have been tested for their ability to inhibit the vaccinia particle deoxyribonucleic acid-dependent ribonucleic acid (RNA) polymerase in vitro. Some compounds are inactive even at concentrations of 500 μg/ml, others are able to produce partial inhibition, and others strongly inhibit the enzyme activity at 150 μg/ml or less. The inhibition, where present, operates immediately but appears to be at least partially reversible. At least one compound which is without effect against bacterial RNA polymerase is a potent inhibitor of the viral RNA polymerase. As the enzyme activity of rifampin-resistant mutants of vaccinia virus is inhibited to the same extent as that of the wild type, the observed in vitro effect on vaccinia virus RNA polymerase is not identical with the in vivo effect specifically directed against a vaccinia-specified protein.
机译：已经测试了许多与利福平的利福平有关的化合物，其已经测试了它们在体外抑制疫苗颗粒脱氧核糖核酸依赖性核糖核酸（RNA）聚合酶的能力。一些化合物即使在500μg/ ml的浓度下也是无活性的，其他化合物能够产生部分抑制，并且其他化合物能够强烈抑制150μg/ ml或更低的酶活性。存在于存在的抑制立即操作但似乎至少部分可逆。对细菌RNA聚合酶的至少一种没有效果的化合物是病毒RNA聚合酶的有效抑制剂。由于疫苗病毒的利福平抗性突变体的酶活性被抑制到与野生型的程度相同，因此观察到对痘苗病毒RNA聚合酶的体外影响与特异性指定疫苗特异性的体内效应不相同蛋白质。

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