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首页> 外文期刊>Journal of Virology >Nonviral Microbodies with Viral Antigenicity Produced in Cytomegalovirus-Infected Cells
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Nonviral Microbodies with Viral Antigenicity Produced in Cytomegalovirus-Infected Cells

机译：非血管微生物与患有病毒抗原的细胞病毒感染细胞

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Masses of homogeneous electron-dense material accumulate in the cytoplasmic inclusions of cultured fibroblasts which have been infected with “wild” and “adapted” strains of human cytomegalovirus. The substance appears to be produced by microtubular membranes and the Golgi apparatus; ultrastructural histochemistry suggests that it is not lysosomal in nature nor is it comprised of lipids or polysaccharides. The dense material “buds” into cytoplasmic tubules forming circumscribed bodies having an investing membrane similar to the viral envelope. After transport to the extracellular milieu in cytoplasmic tubules and vesicles, virions and dense bodies can be demonstrated by immune electron microscopy. The homogeneous dense body appears to be a unique product of the cytomegalovirus-infected cell which possesses a limiting membrane having antigenic determinants common with the viral envelope.
机译：均匀电子 - 密集材料的质量积聚在培养的成纤维细胞的细胞质夹杂物中，这些培养的​​成纤维细胞被感染“野生”和“适应”的人巨细胞病毒。该物质似乎是通过微管膜和GOLGI装置产生的;超微结构组织化学表明它本质上不是溶酶体，也不是由脂质或多糖组成的。将致密材料“芽”成细胞质小管，形成具有类似于病毒包络的投资膜的外接夹层。在细胞质小管中运输到细胞外环境，可以通过免疫电子显微镜证明病毒粒子和致密体。均匀致密的体似乎是巨细胞病毒感染细胞的独特产物，其具有具有与病毒包络常见的抗原决定簇的限制膜。

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