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首页> 外文期刊>Journal of Virology >Nonproductive Infection and Induction of Cellular Deoxyribonucleic Acid Synthesis by Bovine Adenovirus Type 3 in a Contact-Inhibited Mouse Cell Line
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Nonproductive Infection and Induction of Cellular Deoxyribonucleic Acid Synthesis by Bovine Adenovirus Type 3 in a Contact-Inhibited Mouse Cell Line

机译：在接触抑制小鼠细胞系中牛腺病毒3型牛腺病毒型细胞脱氧核酸合成的非培养感染和诱导

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摘要

Bovine adenovirus type 3 (BAV-3), which has been reported to produce tumors in newborn hamsters, induced cellular deoxyribonucleic acid (DNA) synthesis in a contact-inhibited mouse kidney cell line (C3H2K). In this system, the virus did not multiply, whereas virus-specific tumor antigen (T antigen) was detected in nearly all cells. Replication of viral DNA could not be detected by DNA-DNA hybridization on membrane filters. The cellular DNA synthesis induced by BAV-3 did occur in the absence of added serum. Extent of induction of cellular DNA synthesis was closely correlated with the multiplicity of infection. Cells activated to synthesize DNA in the serum-free medium by the virus infection progressed to cell division without noticeable cell killing.
机译：牛腺病毒类型3（BAV-3），已据报道，在新生儿仓鼠中产生肿瘤，诱导诱导抑制小鼠肾细胞系（C3H 2克）中的细胞脱氧核糖核酸（DNA）合成。在该系统中，病毒没有倍增，而在几乎所有细胞中检测到病毒特异性肿瘤抗原（T抗原）。通过在膜过滤器上的DNA-DNA杂交不能检测到病毒DNA的复制。 BAV-3诱导的细胞DNA合成在没有添加的血清的情况下发生。诱导细胞DNA合成的程度与多重感染密切相关。通过病毒感染通过病毒感染激活在无血清培养基中合成DNA，进入细胞分裂而没有明显的细胞杀灭。

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