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首页> 外文期刊>Infection and immunity >Nature of 'memory' in T-cell-mediated antibacterial immunity: anamnestic production of mediator T cells.
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Nature of 'memory' in T-cell-mediated antibacterial immunity: anamnestic production of mediator T cells.

机译:T细胞介导的抗菌免疫“记忆”的性质:介质介质T细胞的anamnestic生产。

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Mice that survived an immunizing infection with Listeria monocytogenes remained specifically resistant to lethal secondary infection for several months. This acquired, long-lived state of resistance was not dependent on activated macrophages that remained after the primary response. It depended, instead, on an acquired long-lived capacity on the part of immunized mice for generating mediator T cells faster and in larger numbers than normal mice. The number of mediator T cells generated in response to secondary infection was proportional to the level of infection. The results suggest that the accelerated production of mediator T cells that occurs in response to secondary infection represents the expression of a state of immunological T-cell memory.
机译:幸存下李斯特菌单核细胞增生的小鼠仍然对致命的继发感染有特异性的几个月。这种获得的长寿状态不依赖于初级反应后保持的活化巨噬细胞。相反,它依赖于免疫小鼠的基础上获得的长寿命能力,用于更快地产生介质T细胞和比正常小鼠更大的数量。响应于二次感染产生的介质T细胞的数量与感染水平成比例。结果表明,响应次级感染响应响应的介质T细胞的加速生产代表了免疫T细胞记忆状态的表达。

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  • 来源
    《Infection and immunity》 |1975年第4期|共7页
  • 作者

    R J North;

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  • 收录信息 美国《科学引文索引》(SCI);
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