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首页> 外文期刊>Infection and immunity >Multiple sclerosis-induced reduction in the yield of a mouse cell line.
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Multiple sclerosis-induced reduction in the yield of a mouse cell line.

机译：多发性硬化症诱导的小鼠细胞产量的降低。

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摘要

Cultures of a mouse cell line (PAM) were treated with 71 multiple sclerosis (MS) and 45 non-MS samples. Of the cultures treated with MS material, 80 percent (58) showed a reduction in cell yield (compared to untreated controls) of at least 20 percent by the third passage after inoculation. The MS samples were from 40 MS cases, and a total of 36 cases yielded at least one positive sample. The agent responsible for the decrease was not limited to nervous tissue, but was also found in serum, cerebrospinal fluid, spleen, kidney, and lymph node of MS patients. Positive samples were present at every stage of the disease. None of the non-MS samples yielded cell counts significantly different from untreated controls. The non-MS category included 12 samples from healthy individuals, 13 assorted non-central nervous system disease samples, and the following central nervous system disease samples: six subacute sclerosing panencephalitis, three Huntington's chorea, two Parkinsonism, six amyotrophic lateral sclerosis, one stroke, one encephalopathy, and one epilepsy. Brain homogenates from mice inoculated with MS tissues elicited the decrease, whereas brain homogenates from mice inoculated with non-MS samples did not.
机译：用71个多发性硬化（MS）和45个非MS样品处理小鼠细胞系（PAM）的培养物。在用MS材料处理的培养物中，80％（58）显示在接种后第三次通过第三通道的细胞产率（与未处理对照相比）的降低。 MS样品为40 ms病例，共36例产生至少一个阳性样品。负责减少的药剂不仅限于神经组织，而且还发现在MS患者的血清，脑脊液，脾，肾脏和淋巴结中。在疾病的每个阶段存在阳性样品。没有任何非MS样品产生细胞计数与未经处理的对照显着不同。非MS类别包括来自健康个体的12个样本，13种什锦非中枢神经系统疾病样本，以及以下中枢神经系统疾病样本：六个亚瑟末期硬化脑膜炎，三个亨廷顿的舞蹈病，两个帕金森主义，六个肌萎缩的侧面硬化，一步，一个脑病和一个癫痫。从MS组织接种的小鼠的脑匀浆引发了降低，而用非MS样品的小鼠脑匀浆没有。

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