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Fate of input oncornavirion RNA--biological studies.

机译:输入on Cornavirion RNA - 生物学研究的命运。

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The fate of input Friend leukemia virus RNA was studied using labeled input virus. The appearance of nuclear RNA-DNA hybrid molecules and the apparent integration of input virion RNA with host cell DNA was studied using a series of inhibitors of DNA or protein synthesis, cell growth conditions, and an intercalating agent. Under all these conditions of infection, little to no viral-specific RNA-DNA hybrid molecules were formed. These data demonstrate that the formation of such RNA-DNA hybrid structures requires conditions of infection that allow provirus synthesis and integration. Furthermore, they suggest that at least a fraction of input virion RNA may transiently become integrated with host cell DNA.
机译:使用标记的输入病毒研究了输入朋友白血病病毒RNA的命运。使用一系列DNA或蛋白质合成,细胞生长条件和插入剂研究了核RNA-DNA杂化分子的外观和输入的病毒尼河RNA与宿主细胞DNA的表观整合。在所有感染条件下,没有形成少量的病毒特异性RNA-DNA杂化分子。这些数据表明,这种RNA-DNA杂交结构的形成需要感染条件,允许潜意识合成和整合。此外,它们表明至少一部分输入的病毒虫RNA可以瞬时与宿主细胞DNA集成。

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