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首页> 外文期刊>Journal of Virology >Identification of a herpesvirus isolated from cytomegalovirus-transformed human cells.
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Identification of a herpesvirus isolated from cytomegalovirus-transformed human cells.

机译：鉴定与巨细胞病毒转化的人细胞分离的疱疹病毒。

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摘要

Human cells transformed by cytomegalovirus and transplanted to athymic nude mice yielded a cytopathic virus, Hershey Medical Center virus, following prolonged in vitro passage of the tumor cells. The virus is a double-enveloped herpesvirus, is sensitive to ether, and is inhibited by iododeoxyuridine. No significant antigenic relationship to herpes simplex virus was detected using herpes simplex virus-immune sera in neutralization and immunofluorescence tests, but indirect immunofluorescence tests revealed cytomegalovirus-related antigenicity. Further immunological tests revealed that Hershey Medical Center virus is antigenically indistinguishable from infectious bovine rhinotracheitis virus. Thus, it appears that Hershey Medical Center virus is infectious bovine rhinotracheitis virus, which presumably appeared in the cell culture as a contaminant from fetal calf serum.
机译：通过巨细胞病毒转化并移植到无肠裸鼠的人细胞产生了肿瘤细胞的体外通道后的细胞病病毒Hershey Medical Center病毒。病毒是双包络疱疹病毒，对乙醚敏感，并被碘脱氧尿苷抑制。使用疱疹病毒免疫血清检测到与中和和免疫荧光试验中的疱疹病毒未进行显着的抗原关系，但间接免疫荧光试验显示巨细胞病毒相关的抗原性。进一步的免疫测试显示，Hershey医疗中心病毒从传染性牛鼻窦炎病毒抗原地区别。因此，Hershey Medical Center病毒似乎是传染性牛鼻窦炎病毒，其可能出现在细胞培养中作为来自胎牛血清的污染物。

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