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首页> 外文期刊>Journal of Virology >Primate retroviruses: immunological cross-reactivity between major structural proteins of new and old world primate virus isolates.
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Primate retroviruses: immunological cross-reactivity between major structural proteins of new and old world primate virus isolates.

机译：灵长类动物逆转录病毒：新旧世界灵长类动物病毒分离株主要结构蛋白质之间的免疫交叉反应性。

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摘要

The major 35,000-molecular-weight internal antigen (p35) of the squirrel monkey retrovirus (SMRV) was isolated and partially characterized. Immunological analysis of SMRV p35 led to the demonstration of antigenic determinants common to SMRV and the Mason-Pfizer monkey virus (MPMV). A broadly reactive competition immunoassay was developed utilizing antiserum to MPMV to precipitate 125I-labeled SMRV p35. Although the major structural proteins of MPMV and SMRV competed with equal efficiency in this assay, type B and type C oncornavirus proteins lacked detectable reactivity. Antibodies reactive with the major structural proteins of both MPMV and SMRV were observed in sera of several normal rhesus monkeys with known prior exposure to MPMV-infected animals. These findings demonstrate the ability of sera from naturally immunized primates to recognize broadly reactive interspecies antigenic determinants shared by the major structural proteins of type D oncornaviruses, and they suggest possible horizontal transmission of MPMV among rhesus monkeys. Although sera from a number of squirrel monkeys contained antibody to SMRV p35, the possibility that this latter reactivity was due to endogenous virus activation rather than horizontal transmission cannot be ruled out.
机译：分离和部分表征静脉猴逆转录病毒（SMRV）的主要35,000分子量内抗原（P35）。 SMRV P35的免疫学分析导致​​SMRV常见的抗原决定簇和梅森 - 辉瑞猴病毒（MPMV）的证明。利用抗血清产生广泛的反应性竞争免疫测定，以沉淀125i标记的SMRV P35。尽管MPMV和SMRV的主要结构蛋白在该测定中具有相等效率的竞争，但B型和C型Connavirus蛋白缺乏可检测的反应性。在几个正常恒河猴的血清中观察到与MPMV和SMRV的主要结构蛋白质反应的抗体，其中已知以先前暴露于MPMV感染的动物。这些研究结果表明，血清从天然免疫的灵长类动物识别由D on CornaViruses的主要结构蛋白共享的广泛反应性的抗原决定因素，它们表明恒河猴中MPMV的水平传输。虽然来自许多静脉猴的血清含有SMRV P35的抗体，但是这种后一种反应性的可能性是由于内源性病毒激活而不是水平传输不能排出。

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