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首页> 外文期刊>Journal of Virology >Relationship of retrovirus polyprotein cleavages to virion maturation studied with temperature-sensitive murine leukemia virus mutants.
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Relationship of retrovirus polyprotein cleavages to virion maturation studied with temperature-sensitive murine leukemia virus mutants.

机译：逆转录病毒聚丙烯切割与温度敏感小鼠白血病病毒突变体研究的病毒素愈合的关系。

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摘要

Murine leukemia virus mutants ts3 (Moloney) and ts24 (Rauscher) both formed late-budding structures on the cell membrane at restrictive temperature. They both accumulated core polyproteins Pr65gag and Pr180gag-pol in cell membranes, but the envelope precursor was rapidly turned over. After shift to permissive temperature in the presence of cycloheximide, the accumulated precursors were sequentially cleaved via discrete intermediates both during the final stages of the budding process and in newly released virions to yield the finished virion core proteins and reverse transcriptase. The precursor form of reverse transcriptase was not enzymatically active and became activated partially or entirely inside released virions.
机译：鼠白血病病毒突变体TS3（Moloney）和TS24（RaUscher）在限制温度下形成细胞膜上的后芽结构。它们都累积了核心多蛋白PR65GAG和PR180GAG-POL在细胞膜中，但包膜前体迅速翻转。在在环己酰亚胺存在下转移到允许温度之后，在萌芽过程的最终阶段和新释放的病毒中依次通过离散的中间体顺序地切割累积的前体，以产生成分的病毒核核心蛋白和逆转录酶。逆转录酶的前体形式未酶促活性，并在释放的病毒中部分或完全在释放的病毒中活化。

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