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Analysis of translational products of Friend strain of spleen focus-forming virus.

机译:脾脏聚焦成对病毒交易菌株翻译产品分析。

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We have analyzed normal rat kidney cells nonproductively infected with the Friend strain of spleen focus-forming virus (SFFV) for the presence of murine leukemia virus-specific type C viral proteins. SFFV was found to code for the p15 and p12 proteins of Friend-murine leukemia virus as determined by immunological typing of their antigenic determinants. Molecular-size analysis of p15 and p12 proteins in SFFV nonproductively infected normal rat kidney cells indicated that these proteins are translated as parts of polyprotein molecules. The apparent molecular weights of the polypeptides bearing p12 antigenic determinants revealed the presence of translational products of the SFFV genome that could not be accounted for by know type C virus helper structural proteins.
机译:我们已经分析了正常的大鼠肾细胞,未经生产的脾脏聚焦病毒(SFFV)的脾脏感染菌株用于鼠白血病病毒特异性C类病毒蛋白的存在。通过免疫分类的抗原决定簇来确定,发现SFFV代码为朋友 - 鼠白血病病毒的P15和P12蛋白。 P15和P12蛋白的分子尺寸分析在SFFV非生产感染的正常大鼠肾细胞中表明这些蛋白质被翻译为多蛋白分子的一部分。含有P12抗原决定簇的多肽的表观分子量揭示了SFFV基因组的平移产物的存在,不能通过知道C型病毒辅助结构蛋白来核对。

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