5'-terminal nucleotide sequences of mammalian type C helper viruses are conserved in the genomes of replication-defective mammalian transforming viruses.

S R Tronick; C D Cabradilla; S A Aaronson; W A Haseltine

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5'-terminal nucleotide sequences of mammalian type C helper viruses are conserved in the genomes of replication-defective mammalian transforming viruses.

机译：哺乳动物C辅助病毒的5'-末端核苷酸序列在复制缺陷哺乳动物转化病毒的基因组中被保守。

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The RNAs of replication-defective murine and primate type C transforming viruses were analyzed for the presence of nucleotide sequences homologous to the genomes of their respective helper type C viruses by using DNAs complementary (cDNA) to either the 5'-terminal (cDNA5') or total (cDNAtotal) nucleotide sequences of the helper virus RNA. The defective viruses examined have previously been shown to vary in their ability to express helper viral gag gene proteins. With cDNAtotal as a probe, these transforming viruses were shown to vary in their representation of helper sequences (15 to 60% hybridization of cDNAtotal). In striking contrast, 5'-terminal-specific sequences of the helper virus were conserved in the RNAs of every transforming virus tested (is greater than 80% hybridization of cDNA5'). These findings suggest a critical role for these sequences in the life cycle of the defective transforming virus.

机译：通过使用DNAS互补（cDNA）将DNAs互补（cDNA5'）分析对其各自的辅助C病毒的基因组同源的核苷酸序列的存在，分析了复制缺陷的鼠和灵长类型C转化病毒的RNA。辅助病毒RNA的总（CDNatotal）核苷酸序列。先前所检验的缺陷病毒已被证明可以表达辅助病毒GAG基因蛋白的能力变化。通过作为探针的Cdnatotal，这些转化病毒被证明在它们的辅助序列的表示中变化（15至60％的CDNatotal杂交）。在引人注目的对比中，每个转化病毒的RNA的辅助病毒的5'-末端特异性序列被保守（大于CDNA5的80％杂交）。这些发现表明了缺陷转化病毒的生命周期中这些序列的关键作用。

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《Journal of Virology》 |1978年第3期|共7页
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S R Tronick; C D Cabradilla; S A Aaronson; W A Haseltine;
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收录信息美国《科学引文索引》(SCI);
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1. 5'-terminal nucleotide sequences of mammalian type C helper viruses are conserved in the genomes of replication-defective mammalian transforming viruses. [J] . S R Tronick, C D Cabradilla, S A Aaronson, Journal of Virology . 1978,第3期

机译：哺乳动物C辅助病毒的5'-末端核苷酸序列在复制缺陷哺乳动物转化病毒的基因组中被保守。
2. 5'-terminal nucleotide sequences of mammalian type C helper viruses are conserved in the genomes of replication-defective mammalian transforming viruses. [J] . S R Tronick, C D Cabradilla, S A Aaronson, Journal of Virology . 1978,第3期

机译：哺乳动物C辅助病毒的5'-末端核苷酸序列在复制缺陷哺乳动物转化病毒的基因组中被保守。
3. Variation in nucleotide sequences coding for the N-terminal regions of the matrix and nonstructural proteins of influenza A viruses. [J] . R M Hall, G M Air Journal of Virology . 1981,第1期

机译：流感病毒基质和非结构蛋白的N-末端区域编码的核苷酸序列的变化。
4. A Role for Cyclic Nucleotide-Gated Channels in the Capacitation of Mammalian Sperm [C] . Cisneros-Mejorado A. Sanchez D Western Pharmacology Society . 2011

机译：循环核苷酸门控通道在哺乳动物精子的电容中的作用
5. Cell tropism predicts long-term nucleotide substitution rates of mammalian RNA viruses [D] . Hicks, Allison 2013

机译：细胞趋向性预测哺乳动物RNA病毒的长期核苷酸取代率
6. 5-terminal nucleotide sequences of mammalian type C helper viruses are conserved in the genomes of replication-defective mammalian transforming viruses. [O] . S R Tronick, C D Cabradilla, S A Aaronson, 1978

机译：哺乳动物C型辅助病毒的5端核苷酸序列在复制缺陷型哺乳动物转化病毒的基因组中保守。
7. 5'-terminal nucleotide sequences of mammalian type C helper viruses are conserved in the genomes of replication-defective mammalian transforming viruses [O] . S R Tronick, C D Cabradilla, S A Aaronson, 1978

机译：哺乳动物类型C辅助病毒的5'-末端核苷酸序列在复制缺陷哺乳动物转化病毒的基因组中被保守

5'-terminal nucleotide sequences of mammalian type C helper viruses are conserved in the genomes of replication-defective mammalian transforming viruses.

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