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首页> 外文期刊>Journal of Virology >Epstein-Barr virus-specific DNase activity in nonproducer Raji cells after treatment with 12-o-tetradecanoylphorbol-13-acetate and sodium butyrate.
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Epstein-Barr virus-specific DNase activity in nonproducer Raji cells after treatment with 12-o-tetradecanoylphorbol-13-acetate and sodium butyrate.

机译：在用12-O-四癸酰基酚-13-乙酸盐和丁酸钠处理后，Epstein-BART病毒特异性DNA酶活性。

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摘要

An Epstein-Barr virus (EBV)-specific DNase was induced in EBV nonproducer Raji cells after treatment with 12-O-tetradecanoylphorbol-13-acetate and sodium butyrate. The increase in EBV DNase activity was related to the appearance of early antigen-positive cells. The enzyme had a sedimentation coefficient of 4S and was resistant to 300 mM KCl, and its induction did not depend on viral DNA synthesis. The EBV-specific DNase activity was specifically inhibited by sera from patients who had nasopharyngeal carcinoma with high early antigen activities but not by sera from normal, healthy individuals. There was a correlation between the degree of anti-EBV DNase activity and the titers of early antigen antibody.
机译：在用12-O-四癸酰卟啉-13-乙酸盐和丁酸钠处理后，在EBV非产杆Raji细胞中诱导了Epstein-BARR病毒（EBV）-PectificDNase。 EBV DNase活性的增加与早期抗原阳性细胞的出现有关。酶的沉降系数为4S，耐300mM KCl，其诱导不依赖于病毒性DNA合成。来自患有高早期抗原活性的患者的血清特别抑制EBV特异性DNase活性，但不是来自正常，健康个体的血清。抗EBV DNase活性与早期抗原抗体的滴度之间存在相关性。

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