...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Virology >Lack of neutralizing antibodies to caprine arthritis-encephalitis lentivirus in persistently infected goats can be overcome by immunization with inactivated Mycobacterium tuberculosis.
【24h】

Lack of neutralizing antibodies to caprine arthritis-encephalitis lentivirus in persistently infected goats can be overcome by immunization with inactivated Mycobacterium tuberculosis.

机译：通过免疫分枝杆菌的免疫，可以克服缺乏对普遍感染的山羊的牙龈关节炎 - 脑炎的中和抗体。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The pathogenesis of the persistent progressive diseases of sheep (visna-maedi) and goats (arthritis-encephalitis) is dependent on continuous replication of the causative lentiviruses. One subgroup of these viruses, Icelandic visna virus, accomplishes this form of replication by undergoing antigenic mutation. Mutant viruses arising late in the infection escape neutralization by antibodies directed to the parental virus. In contrast, we show here that viruses obtained from persistently infected sheep and goats with natural disease in this country do not induce virus-neutralizing antibodies, although antibodies to virus core proteins were produced. The lack of neutralizing antibodies was not overcome by hyperimmunization of animals with concentrated preparations of live or inactivated virus. Thus, failure to produce these specific antibodies was not due to lack of sufficient antigen or interference with the immune response because of the ability of these viruses to infect macrophages. The hyporesponsive state, however, was overcome by immunization of animals with virus and large amounts of inactivated Mycobacterium tuberculosis. Induction of agglutinating and neutralizing antibodies by this method was probably due to a unique form of antigen processing by macrophages activated by M. tuberculosis. Neutralizing antibodies were produced for the first time against the caprine arthritis-encephalitis virus by this method. These antibodies have similar biological properties to those induced by Icelandic visna virus. They belong to the immunoglobulin G1 subclass, they are effective against a narrow range of caprine arthritis-encephalitis viruses, and they identify (for the first time) antigenic variants among these caprine agents.
机译：羊（visna-maedi）和山羊（关节炎 - 脑炎）的持续性渐进疾病的发病机制依赖于致病慢病毒的连续复制。这些病毒，冰岛毒病病毒的一个亚组通过接受抗原突变来完成这种形式的复制。通过针对父母病毒的抗体在感染中产生的突变病毒逃逸中和。相比之下，我们展示了从持续受感染的绵羊和具有本国自然疾病的山羊获得的病毒不会诱导病毒中和抗体，尽管产生了对病毒核心蛋白的抗体。通过浓缩或灭活病毒的浓缩制剂的动物超免疫，不会克服缺乏中和抗体。因此，由于这些病毒感染巨噬细胞的能力，未缺乏足够的抗原或干扰免受足够的抗原或干扰来产生这些特异性抗原。然而，通过用病毒免疫和大量的灭活分枝杆菌的动物免疫动物克服了低响应状态。通过该方法诱导凝集和中和抗体的抗体可能是由于由M.结核病激活的巨噬细胞的独特形式的抗原处理。通过该方法首次抵抗Caprine关节炎 - 脑炎病毒首次产生中和抗体。这些抗体具有与冰岛visna病毒诱导的那些类似的生物学性质。它们属于免疫球蛋白G1亚类，它们有效针对狭窄程度的Caprine关节炎 - 脑炎病毒，并且它们鉴定（第一次）这些葡萄酒代理中的抗原变体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号