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首页> 外文期刊>Nucleic acids research >Immunological end spectroscopic studies of poly(dG-dC).poly(dG-dC) modified by cis-diamminedicholoroplatinum(II)
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Immunological end spectroscopic studies of poly(dG-dC).poly(dG-dC) modified by cis-diamminedicholoroplatinum(II)

机译：CIS-DIAMICHICHICHOLOLOLOLINUM（II）改性的聚（DG-DC）.poly（DG-DC）的免疫结束光谱研究

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摘要

The conformational changes induced by the binding of cis-diamminedichlo-roplatinum(II) to poly(dG-dC).poly(dG-dc) have been studied by reaction with specific antibodies, by circular dichroism and 3 nuclear magnetic resonan ce. Polyclonal and monoclonal antibodies to Z-DNA bind to platinated poly(dG-dC).poly(dG-dc) at low and high ionic strength. Antibodies elicited in rabbits immunized with the platinated polynucleotide bind to double stranded polynucleotides known to adopt the Z-conformation. At low and high ionic strength the circular dichroism spectrum of platinsted poly(dG-dC).poly(dG-dC) does not resemble that of poly(dG-dC) .poly(dG-dC) (B or Z conformation). At low ionic strength, the characteristic 31P nuclear magnetic resonance spectrum of the Z-form is not detected. It appears only at high ionic strength, as a component of a more complex spectrum.
机译：通过与特异性抗体的反应研究了CIS-DIAMMOINMOINICHLO-ROPTINUM（II）与聚（DG-DC）.poly（DG-DC）的构象变化。多克隆和单克隆抗体对Z-DNA的抗体以低和高离子强度结合浸渍聚（DG-DC）.pold（DG-DC）。在用丁化多核苷酸免疫的兔中引发的抗体结合了已知采用Z构象的双链多核苷酸。在低和高离子强度下，镀铂聚（DG-DC）.poly（DG-DC）的圆形二色性谱不像聚（DG-DC）.poly（DG-DC）（B或Z构象）。在低离子强度下，未检测到Z形式的特性 31核磁共振谱。它仅以高离子强度显示，作为更复杂的光谱的组分。

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