...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Virology >Monkey B-lymphotropic papovavirus DNA: nucleotide sequence of the region around the origin of replication.
【24h】

Monkey B-lymphotropic papovavirus DNA: nucleotide sequence of the region around the origin of replication.

机译：猴B-onphoppic papovavirus DNA：该区域围绕复制起源的核苷酸序列。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We have determined the nucleotide sequence of the HindIII-B DNA segment of African green monkey B-lymphotropic papovavirus (LPV), which shows a highly restricted host range and whose genome is a 5.1-kilobase-long circular DNA. The segment, consisting of 1,123 base pairs, contained the origin of DNA replication, the putative control region for early transcription, and the region probably coding for the amino-terminal portion of T antigens. The symmetrical region at the center of replication origin, 5'-GAGGC CA GGGGCCCC TA GCCTC-3' (on the L strand), has diverged in the central portion from the corresponding regions of primate polyomaviruses simian virus 40, BK virus, and JC virus, but resembles that of mouse polyomavirus. The structure of the control region upstream of the replication origin was unique to LPV and contained several repeated sequences, the longest of which were two 60-base-pair tandem repeats. The amino-terminal region common to LPV small T and large T antigens showed some homology (41%) in the deduced amino acid sequence to that of both simian virus 40 and the mouse polyomavirus. Like other polyomaviruses, the probable carboxyl-terminal region unique to LPV small T antigen contained two sets of the Cys-x-Cys-x-x-Cys structure. These data show that, despite the unique structures in the control region, LPV is evolutionally related to the mouse polyomavirus and to simian virus 40.
机译：我们已经确定了非洲绿色猴B-inMphothropic pavovaVirus（LPV）的HindIII-B DNA片段的核苷酸序列，其显示出高度限制的宿主范围，其基因组是5.1千碱基长的圆形DNA。由1,123个碱基对组成的段包含DNA复制的起源，预测对照区域用于早期转录，并且可能对T抗原的氨基末端部分编码的区域。复制起源中心的对称区域，5'-GAGGC CA GGGGCCC TA GCCTC-3'（在L STRAND上），从激发多立方体猿猴病毒40，BK病毒和JC的相应区域分歧。病毒，但类似于小鼠多瘤病毒。复制原点上游的控制区域的结构对于LPV是独特的，并且包含几种重复序列，其最长是两个60碱基对串联重复。对于LPV小T和大T抗原共同的氨基末端区域显示出推导的氨基酸序列中的一些同源性（41％）与Simian病毒40和小鼠多瘤的氨基酸序列中的一些同源性（41％）。与其他多瘤一样，LPV小T抗原独特的可能羧基末端区域含有两组Cys-X-Cys-X-X-Cys结构。这些数据表明，尽管控制区域中的独特结构，但LPV与小鼠多瘤病毒和Simian病毒40进化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号