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首页> 外文期刊>Journal of Virology >Characteristics and functions of Sendai virus-specific T-cell clones.
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Characteristics and functions of Sendai virus-specific T-cell clones.

机译：仙台病毒特异性T细胞克隆的特征与功能。

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Several murine Sendai virus-specific T-cell clones were characterized in vitro and in vivo. All T-cell clones were phenotypically Thy-1.2+, and most clones were Lyt-1+,2-; one T-cell clone was Lyt-1-,2-. Some of the clones proliferated in response to antigen presented on I region-compatible stimulator cells. Proliferation could be inhibited by monoclonal antibodies directed against class II antigens. Clones which proliferated in response to antigen secreted lymphokines which could be identified as Interleukin 2 and Interleukin 3. All of the clones tested in vivo induced a delayed-type hypersensitivity response in syngeneic mice challenged with antigens. Depending on the experimental conditions chosen, Interleukin 2-producing clones as well as non-Interleukin 2-producing clones mediated help for stimulation of cytolytic T lymphocytes.
机译：几种鼠仙台病毒特异性T细胞克隆在体外和体内表征。所有T细胞克隆都是表型Thy-1.2 +，大多数克隆都是Lyt-1 +，2-;一个T细胞克隆是Lyt-1-，2-。响应于I区域相容刺激细胞的抗原，一些克隆增殖的一些克隆。通过针对II类抗原的单克隆抗体可以抑制增殖。响应于抗原分泌淋巴因子的克隆可以鉴定为白细胞介素2和白细胞介素3.在体内测试的所有克隆诱导与抗原攻击的同联幼鼠中的延迟型超敏反应。取决于所选择的实验条件，产生白细胞介素2的克隆以及非白细胞介素2的产生克隆介导的有助于刺激细胞溶解T淋巴细胞。

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