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首页> 外文期刊>Journal of Virology >Endogenous RD-114 virus genome expression in malignant tissues of domestic cats.
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Endogenous RD-114 virus genome expression in malignant tissues of domestic cats.

机译：国内猫恶性组织中的内源性RD-114病毒基因组表达。

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摘要

Endogenous xenotropic cat type C virus (RD-114)- and infectious feline leukemia virus (FeLV)-specific gene expressions were measured in spontaneous sarcomas carcinomas, and nonmalignant cat tissues by molecular hybridization for virus-specific RNA and competition radio-immunoassays for the major internal protein (p30) of these two viruses. The results indicate that RD-114 gene expression in sarcomas and carcinomas at both RNA and p30 levels is significantly higher than histologically normal tissues from cats free of cancer. In contrast, the levels of FeLV viral RNA and p30 are fount to be low or undetectable in the majority of these tumored and normal tissues examined. Whereas variability in the amounts of RD-114 OR FeLV RNA and p30 expressed is found in tissues from different cats, their expression is fairly uniform in multiple malignant tissues of the same cat. The finding of widespread occurrence of elevated RD-114 gene expression in sarcomas and carcinomas is consistent with our similar observation with natural lymphomas of domestic cats and suggests that expression of certain functions of this endogenous virus may be etiologically involved in the development of many different spontaneous neoplasms of cats.
机译：内源性异常猫型病毒（RD-114） - 和传染性猫科学病毒（FELV）的特异性基因表达在自发的肉瘤中，通过分子杂交对病毒特异性RNA和竞争无线电免疫测定的非alalignant CAT组织这两种病毒的主要内部蛋白质（P30）。结果表明，RNA和P30水平的肉瘤和癌症中的RD-114基因表达明显高于来自猫的组织学常规组织。相比之下，在这些肿瘤和正常组织中的大多数中，FELV病毒RNA和P30的水平是低或未检测到的。然而，在不同猫的组织中发现RD-114或FELV RNA和P30的量的变异性，但它们的表达在同一猫的多个恶性组织中相当均匀。在肉瘤和癌症中升高的RD-114基因表达的发现与我们与国内猫的天然淋巴瘤的类似观察结果一致，表明这种内源性病毒的某些功能的表达可能是病因涉及许多不同自发性的发展猫的肿瘤。

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