首页> 外文期刊>Journal of Virology >Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines.
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Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines.

机译:小鼠FV-1基因座的遗传研究:重组近交系中GPD-1的键合。

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Multiple recombinant inbred lines, derived from crosses between strains permissive to N-tropic murine leukemia viruses (Fv-1n) and strains permissive to B-tropic murine leukemia viruses (Fv-1b), have been characterized as to Fv-1 genotype and other chromosome 4 markers, including the closely linked hexose-6-phosphate dehydrogenase isozyme locus (Gpd-1). Only one recombinant between Fv-1 and Gpd-1 was found among 45 lines tested. On this basis, the distance between Fv-1 and Gpd-1 is estimated to be 0.6 centimorgans. None of the lines was either resistant or susceptible to both N- and B-tropic viruses. Nineteen other inbred strains, previously untested, were characterized as either Fv-1n or Fv-1b.
机译:衍生自诱导对N-热带鼠白血病病毒(Fv-1N)的菌株之间的交叉的多种重组近交系数,并赋予B-热带鼠白血病病毒(FV-1B)的菌株的表征为FV-1基因型和其他染色体4个标记,包括紧密连接的己糖-6-磷酸脱氢酶同工酶(GPD-1)。在测试的45条线中发现了FV-1和GPD-1之间的一个重组剂。在此基础上,FV-1和GPD-1之间的距离估计为0.6厘米。没有任何线耐耐或易于N-和B-热带病毒。 1999年以前未测试的近交菌株的特征在于FV-1N或FV-1B。

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