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首页> 外文期刊>Journal of Virology >Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosine.
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Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosine.

机译：抑制病毒RNA甲基化在疱疹病毒型1感染细胞中的5's-异丁基 - 腺苷。

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摘要

5' S-isobutyl-adenosine (SIBA), a structural analogue of S-adenosylhomocysteine, reversibly blocks the multiplication of herpes simplex type 1 virus. In the presence of SIBA, viral protein synthesis is inhibited. After removing SIBA the synthesis of proteins starts rapidly again. The new polypeptides are mainly alpha proteins (Honess and Roizman, J. Virol. 14:8-19, 1974,), normally the first to be synthesized after infection. The rapid synthesis of proteins after release of inhibition seems to be directed by mRNA formed in the presence of SIBA as indicated by experiments using actinomycin D but which was undermethylated as shown by analysis of methyl groups on RNA. SIBA inhibits the methylation of mRNA and especially that of the 5' cap. Capping of mRNA thus seems to be essential for efficient translation. The analogue affected various methylations to different extents.
机译：5'S-异丁基 - 腺苷（SIBA），S-腺囊肌细胞的结构类似物，可逆地阻断疱疹1型病毒的倍增。在SIBA存在下，抑制病毒蛋白合成。除去SIBA后，蛋白质的合成再次开始迅速。新的多肽主要是α蛋白（Hemess和Roizman，J.Virol。14：8-19,1974，）通常是第一个在感染后合成的。在释放抑制后的快速合成蛋白质似乎是由在SIBA存在下形成的mRNA，如通过使用放射素D的实验所示，但如通过在RNA上的甲基分析所示的甲基化所示。 SIBA抑制mRNA的甲基化，尤其是5'帽的甲基化。因此，mRNA的封盖似乎是有效翻译至关重要。该模拟影响到不同范围的各种甲基化。

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