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首页> 外文期刊>The biochemical journal >Differences between lactating and non-lactating dairy cows in concentration and secretion rate of insulin
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Differences between lactating and non-lactating dairy cows in concentration and secretion rate of insulin

机译：哺乳期与非哺乳酸奶牛浓度和胰岛素分泌率之间的差异

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p1. Four parameters of insulin metabolism were compared in catheterized lactating and non-lactating Friesian x Ayrshire dairy cows. 2. The four parameters, i.e. arterial and portal-venous concentrations of insulin, and pancreatic output and hepatic uptake of insulin, were approx. 2-, 3-, 3- and 5-fold higher respectively in the non-lactating cows than in the lactating cows in the normal fed state. Statistical significance was not achieved for the differences in magnitude in the case of the latter two parameters, however. 3. All four parameters increased significantly about 4-fold when non-lactating cows were infused intravenously with glucose for 48 h at a rate of 4.2 mmol/min. The parameters also increased in the lactating cows during glucose infusion, but the values reached were substantially lower than in the non-lactating cows and the increases were not statistically significant. 4. Arterial insulin concentrations doubled in the non-lactating cows during a 3 h infusion of propionate into a mesenteric vein, but remained unaltered in the lactating cows. 5. Differences in insulin concentration and output between the lactating and non-lactating cows were not consistently related to differences in either glucose concentration or glucose-entry rate. Arterial propionate concentrations were similar in both groups of cows at all times. 6. It is concluded that in the dairy cow, insulin secretion in response to an insulinotropic agent is diminished during lactation./p
机译：> 1。比较了胰岛素代谢的四个参数，在导管哺乳酸和非哺乳期X Ayrshire乳制奶牛中进行了比较。 2.四个参数，即动脉和门静脉浓度的胰岛素和胰岛素的胰腺输出和胰岛素的摄取，约为约。在非哺乳期奶牛中分别比在正常送入状态下的哺乳期奶牛中更高的2-，3-，3-和5倍。然而，对于后两种参数的情况下，差异差异没有实现统计学意义。 3.当非哺乳奶牛用葡萄糖以48小时静脉注入48小时时，所有四个参数大约4倍，以4.2mmol / min的速率。在葡萄糖输注过程中，参数在哺乳期奶牛中也增加，但达到的值基本上低于非乳酸奶牛，并且增加在统计学上没有统计学意义。 4.在将丙酸盐的3小时内输注到肠系膜静脉中，动脉胰岛素浓度增加了非乳酸奶牛，但在哺乳期奶牛中保持不变。 5.泌尿膜和非乳酸奶牛之间胰岛素浓度和输出的差异与葡萄糖浓度或葡萄糖入学率的差异均不始终如一。两组奶牛组中的动脉丙酸盐浓度相似。 6.结论是，在奶牛中，泌乳母牛响应胰岛素的分泌在泌乳期间减少。

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