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首页> 外文期刊>Journal of Virology >Guanidine-sensitive Na+ accumulation by poliovirus-infected HeLa cells.
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Guanidine-sensitive Na+ accumulation by poliovirus-infected HeLa cells.

机译：胍敏感的Na +通过Poliovirus感染的HeLa细胞积累。

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摘要

The Na+ content of poliovirus-infected HeLa S3 cells increased during the late phase of virus replication, after virus inhibition of host cell protein synthesis and in coincidence with late viral functions. Guanidine hydrochloride blocked the rise in Na+ content, whereas the antiguanidine agent choline fully reversed the guanidine block. Expression of one or more late viral functions was essential for Na+ accumulation to occur because accumulation was inhibited by cycloheximide or guanidine added to the infected culture during the late phase. Increased adenosine triphosphatase activity appears to be primarily responsible for Na+ accumulation by virus-infected cells.
机译：在病毒复制后期的脊髓灰质炎病毒感染的HeLa S3细胞的Na +含量增加，病毒抑制宿主蛋白合成和具有晚期病毒功能的巧合。盐酸胍含有植物的兴起，而抗原胺胆碱完全逆转胍嵌段。一种或多种晚期病毒功能的表达对于纳+积累是必不可少的，因为在晚期期间通过环己酰亚胺或胍抑制积累的积累。增加的腺苷三磷酸酶活性似乎主要对病毒感染细胞的Na +积累主要负责。

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