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首页> 外文期刊>Journal of Virology >Defective retrovirus-like 30S RNA species of rat and mouse cells are infectious if packaged by type C helper virus.
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Defective retrovirus-like 30S RNA species of rat and mouse cells are infectious if packaged by type C helper virus.

机译：如果通过C型辅助病毒包装，有缺陷的逆转录病毒样品大鼠和小鼠细胞的RNA和小鼠细胞的物种是传染性的。

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摘要

RNA species with properties of defective retrovirus-like 30S RNA genomes have previously been detected in both rats and mice and in some rat and mouse retroviruses. Using cell lines which express high levels of this retrovirus-like RNA, we formed pseudotypes of the 30S RNAs with helper-independent type C viruses. A pseudotype virus complex containing a mouse 30S subunit was transmitted to rat cells, and a pseudotype virus complex containing a rat 30S subunit was transmitted to bat cells. In other transmission experiments, a rat 30S subunit was isolated in nonproducer bat cells without detectable expression of the helper-independent type C virus used to pseudotype it. The results provide further support for the retrovirus-like nature of the rat 30S subunit and provide evidence which supports the protovirus hypothesis proposed by Temin.
机译：预先在大鼠和小鼠中检测到具有缺陷逆转录病毒样30S RNA基因组的性质的RNA物种，并在一些大鼠和小鼠逆转录病毒中检测到。使用表达高水平的这种逆转录病毒样RNA的细胞系，我们用辅助型C病毒形成30S RNA的假型。将含有小鼠30s亚单位亚单位的假型病毒络合物传递给大鼠细胞，并将含有大鼠30s亚单位的伪型病毒络合物传递给蝙蝠细胞。在其他传输实验中，在非产蛋白蝙蝠细胞中分离大鼠30s亚基，而不可检测到辅助无关的C型病毒的表达，用于假型。结果为大鼠30s亚基的逆转录病毒样本提供了进一步的支持，并提供支持Temin提出的Protovirus假设的证据。

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