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首页> 外文期刊>Journal of Virology >Transformation phenotype of polyoma virus-transformed rat fibroblasts: plasminogen activator production is modulated by the growth state of the cells and regulated by the expression of an early viral gene function.
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Transformation phenotype of polyoma virus-transformed rat fibroblasts: plasminogen activator production is modulated by the growth state of the cells and regulated by the expression of an early viral gene function.

机译:多瘤病毒转化大鼠成纤维细胞的转化表型:纤溶酶原激活剂产生通过细胞生长状态调节,并通过早期病毒基因功能的表达调节。

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摘要

The expression of two transformation parameters, namely, ability to grow in agar and plasminogen activator production, was studied in several rat fibroblasts transformed by either wild-type or thermo-sensitive (tsa and ts25) polyoma viruses. The production of plasminogen activator was found to be dependent upon the growth state of the infected cells during a period of several days after infection. The analysis of the transformed phenotype of 25 tsa transformants and of 19 ts25 transformants independently isolated under various growth conditions led to the conclusion that there is no correlation between the regulation processes involved in plasminogen activator production and ability to grow without anchorage. The results obtained also suggested that the production of plasminogen activator is under the control of a functional large T antigen.
机译:通过野生型或热敏(TS25)多环病毒转化的几只大鼠成纤维细胞中,研究了两种转化参数的表达,即琼脂和纤溶酶原激活剂产生的能力。发现纤溶酶原激活剂的产生依赖于感染后几天感染细胞的生长状态。在各种生长条件下独立隔离的25tS转化体和19ds25转化体的转化表型的分析导致了纤溶酶原激活剂产生的调控过程与没有锚固的能力之间没有相关性的结论。所获得的结果还表明,纤溶酶原激活剂的产生是在功能性大T抗原的控制下。

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  • 来源
    《Journal of Virology》 |1980年第2期|共8页
  • 作者

    B Perbal;

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  • 收录信息 美国《科学引文索引》(SCI);
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