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首页> 外文期刊>Journal of Virology >Herpes simplex virus-induced changes in cellular and adenovirus RNA metabolism in an adenovirus type 5-transformed human cell line.
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Herpes simplex virus-induced changes in cellular and adenovirus RNA metabolism in an adenovirus type 5-transformed human cell line.

机译：单纯形病毒诱导的细胞和腺病毒RNA代谢在腺病毒类型5转化的人细胞系中的变化。

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摘要

We used the viral transcripts (designated Ad-RNA) that accumulated in the cytoplasm of adenovirus type 5-transformed human embryonic kidney cells (cell line 291-31) as models for cellular RNAs to examine how herpes simplex virus modifies cellular RNA metabolism. Infection of 293-31 cells with herpes simplex virus type 1 strain 17 lead to extensive inhibition of Ad-RNA accumulation by 4 h postinfection. The major part of this inhibition was due to an immediate early or alpha gene function, which reduced the rate of transcription of Ad-RNA within the nuclei of the infected cells. In addition, host polyadenylic acid-containing RNA accumulation and rRNA accumulation were affected, but to a lesser extent and at lower rate than Ad-RNA accumulation. In conjunction with previous data, our experimental data allowed us to propose a general scheme for how herpes simplex virus type 1 alters the metabolism of cellular RNA, the possible mechanisms for these changes, and how they correlate with the regulation of herpes simplex virus gene expression.
机译：我们使用了在腺病毒型5转化的人胚胎肾细胞（细胞系291-31）的细胞质中累积的病毒转录物（指定的Ad-RNA）作为细胞RNA的模型，以检查单纯疱疹病毒如何改变细胞RNA代谢的疱疹。用疱疹病毒1型菌株17感染293-31细胞，导致4小时内抑制Ad-RNA积累的广泛抑制。该抑制的主要部分是由于早期或α基因函数，这降低了受感染细胞的细胞核内的Ad-RNA的转录速率。此外，含宿主聚腺苷酸的RNA积累和rRNA积累受到影响，但在较小程度上并且以低于ad-RNA积累的速度较低。与以前的数据结合使用，我们的实验数据允许我们提出单纯疱疹病毒类型1如何改变细胞RNA的代谢的一般方案，这些变化的可能机制以及它们如何与单纯疱疹病毒基因表达的调节相关联。

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