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首页> 外文期刊>Journal of Virology >Reexamination of the Morphogenetic Block of a Putative Late-Stage, Temperature-Sensitive Mutant of Moloney Murine Leukemia Virus
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Reexamination of the Morphogenetic Block of a Putative Late-Stage, Temperature-Sensitive Mutant of Moloney Murine Leukemia Virus

机译:重新审查莫尼鼠白血病病毒的推定后期,温度敏感突变体的形态发生块

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The ts3 temperature-sensitive mutant of Moloney murine leukemia virus has been reported to have a morphogenetic block in a late stage of the budding process. As evidence, previously published electron micrographs of cells maintained at the nonpermissive temperature (39°C) revealed numerous budding virions on the cell surface. However, it appears now that these micrographs reflected budding that occurred not at 39°C, but after cells were removed from the incubator before fixation. The morphogenesis of ts3 is actually blocked at an earlier stage of development.
机译:据报道,莫尼鼠白血病病毒的 Ts 3温度敏感突变体在萌芽过程的后期具有形态发生块。作为证据,以前公布的细胞的电子显微照片保持在非智能温度(39℃),在细胞表面上显示了许多萌芽的病毒粒子。然而,现在,这些显微照片反映了在39℃下发生的衰退,但在固定前从培养箱中除去细胞。 TS 3的形态发生在早期的发育阶段被阻止。

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