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The N-ras oncogene assigned to the short arm of human chromosome 1

机译:N-Ras癌基因分配给人染色体的短臂1

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The human N-ras oncogene, Isolated from the HL-60 promyelocytic leukemia cell line, Is distantly related to viral oncogenes of Kirsten and Harvey sarcoma viruses. We have determined its chromosomal location by Southern blot analysis of DNAs from 37 human x rodent hybrid cell lines derived from 8 different human donors, some of whom carried balanced rearrangements of chromosome 1. The results indicate that the N-ras oncogene (RASN) is localized on the proximal part of the short arm of human chromosome 1, in region p3200←cen.
机译:从HL-60临时血细胞白血病细胞系中分离的人N-RAS癌基因与Kirsten和Harvey Sarcoma病毒的病毒诱发癌症远方。我们通过37人X啮齿动物杂交细胞系Southern印迹分析确定了染色体的染色体位置,其中一些不同人类供体源自染色体1的均衡重排。结果表明N-RAS癌基因(RASN)是局部位于人染色体短臂的近端部分1,在区域P3200←CEN中。

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