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首页> 外文期刊>The biochemical journal >Quantification in vivo of the effects of insulin on glucose utilization in individual tissues of warm- and cold-acclimated rats
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Quantification in vivo of the effects of insulin on glucose utilization in individual tissues of warm- and cold-acclimated rats

机译：胰岛素胰岛素效果的定量对暖对大鼠单个组织葡萄糖利用的影响

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pCold-acclimation of rats (3 weeks, 4 degrees C) had no effect on basal rates of glucose production or utilization. Under euglycaemic-clamp conditions, in which the circulating insulin concentration was increased by approx. 50 microunits/ml, cold-acclimated rats showed a greater increase in glucose utilization and a greater suppression of endogenous glucose production. Tissue sites of glucose utilization were investigated by using a tracer dose of 2-deoxy-D-[14C]glucose and a glucose metabolic index determined for each tissue. In 5 h-starved warm-acclimated rats, heart had the highest glucose metabolic index. This was increased further by both cold-acclimation and insulin treatment. The glucose metabolic index of skeletal muscle was 3.5-14-fold lower than that of heart, but, as a result of the large muscle mass, skeletal muscle made the largest contribution to whole-body glucose utilization. White and brown adipose tissue had low glucose metabolic indices in warm-acclimated rats under basal conditions, and the indices were not increased by the insulin treatment. However, cold-acclimation produced a significant increase in the glucose metabolic index of brown adipose tissue, but not of white adipose tissue. In contrast with the warm-acclimated rats, insulin treatment of cold-acclimated rats resulted in a marked increase in the glucose metabolic index of brown adipose tissue. The results provide evidence that cold-acclimation produces a selective alteration in the insulin-sensitivity of brown adipose tissue./p
机译：>大鼠的冷驯化（3周，4℃）对葡萄糖产生或利用的基础速率没有影响。在苛刻的夹杂菌条件下，其中循环胰岛素浓度增加了约。 50微米/ mL，冷适度的大鼠葡萄糖利用率较大，较大抑制内源性葡萄糖生产。通过使用三氧化剂剂量的2-脱氧-D-[14C]葡萄糖和针对每个组织确定的葡萄糖代谢指数来研究葡萄糖利用组织部位。在5个H-STALVED温适的大鼠中，心脏具有最高的葡萄糖代谢指数。通过冷驯化和胰岛素治疗进一步增加了这一点。骨骼肌的葡萄糖代谢指数比心脏低3.5-14倍，但由于肌肉质量大，骨骼肌对全身葡萄糖利用产生了最大贡献。白色和棕色脂肪组织在基础条件下的温暖适应的大鼠中具有低葡萄糖代谢指标，并且胰岛素治疗没有增加索引。然而，冷驯化产生棕色脂肪组织的葡萄糖代谢指数显着增加，但不含白色脂肪组织。与温暖的大鼠相比，冷适应大鼠的胰岛素治疗导致棕色脂肪组织的葡萄糖代谢指数显着增加。结果提供了证据表明，冷驯化产生棕色脂肪组织的胰岛素敏感性的选择性改变。

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