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首页> 外文期刊>Journal of Virology >Nucleotide sequence analysis of squirrel monkey retrovirus reveals a novel primer-binding site for tRNALys1,2.
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Nucleotide sequence analysis of squirrel monkey retrovirus reveals a novel primer-binding site for tRNALys1,2.

机译：松鼠猴逆转录病毒的核苷酸序列分析显示了Trnalys1,2的新型引物结合位点。

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摘要

Nucleotide sequences of a DNA fragment containing the long terminal repeat (LTR) of squirrel monkey retrovirus (SMRV) were determined. Sequence analysis showed that the SMRV LTR is 456 base pairs (bp) long and is bounded by 2-bp inverted repeats. Within the U3 region, there are two 43-bp repeats and two 42-bp repeats which are homologous to each other. These repeats are likely to provide enhancer activities commonly observed in other enhancer sequences. Following the repeats are transcriptional regulatory sequences including a CAT box, a Goldberg-Hogness box, and a polyadenylation signal, all positioned within the U3 region of SMRV LTR. A 22-nucleotide sequence immediately downstream from the LTR was found to be complementary to tRNALys1,2, suggesting that tRNALys1,2 serves as the primer for the reverse transcription of SMRV viral RNA.
机译：确定含有鼠猴逆转录病毒（SMRV）的长末端重复（LTR）的DNA片段的核苷酸序列。序列分析表明，SMRV LTR是456个碱基对（BP），并且由2-BP反相重复界定。在U3区域内，有两个43-BP重复和两个42-BP重复，彼此同源。这些重复可能在其他增强子序列中提供通常观察到的增强剂活动。在重复之后是转录调节序列，包括猫盒，金贝格 - 养猪盒和多腺苷酸化信号，全部位于SMRV LTR的U3区域内。发现直接从LTR下游的22核苷酸序列与Trnalys1,2互补，表明Trnalys1,2用作SMRV病毒RNA逆转录的引物。

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