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Binge-eating behavior in mice: Influences of restriction and palatability in a limited access model.

机译:小鼠暴饮暴食行为:在受限进入模型中限制和适口性的影响。

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摘要

Animal models of bingeing have typically used stress to induce bingeing. A recent model, limited-access to high-fat diet (HFD), has shown that caloric restriction and stress were not required to induce bingeing in rats. This study replicated this model in mice, explored the fat content within the model, and investigated locomotor activation associated with binge-eating. Adult mice were maintained on a restricted feeding (RF) schedule of 2 h/d of access to chow or ad lib access to chow, and then provided limited access to 45% HFD or 84% HFD for 30 min 3 d/week for 6 total snack sessions. Circadian activity was monitored for RF animals offered 84% HFD, and after 6 snack sessions were complete, allowed continuous access to the 45% HFD or the 84% HFD for two weeks to explore rebound feeding. Bingeing, defined by increasing intakes across days, was reported for mice offered 45% HFD regardless of deprivation state (RF or ad lib), while mice offered 84% HFD only exhibited bingeing when they were restricted. Comparison of male and female mice maintained RF, offered 45% HFD snack, showed that females had higher intake (kcals/g-bw) while ad lib fed mice exhibited no sex differences. Circadian recordings for female RF mice offered 84% HFD showed shifts in activity from the first hour of dark cycle to the hour preceding the snack and supported that offering the HFD produced alterations in food-associated arousal. During rebound, female RF mice given 84% HFD showed the highest intakes in week 1, and then exhibited a marked decline in week 2. The week 1 intake for RF animals were to regain lost body weight and that homeostatic-like intake in week 2 allowed normal body weight maintenance.;Results of this investigation support human data that females are more susceptible to binge-type eating disorder, shows that limited access to palatable foods for females under caloric restriction induces changes in circadian activity, and reveals that using mice in this model requires more investigation to optimize binge-behavior. Diet comparisons also suggest that homeostatic and reward mechanisms may have an additive effect on bingeing.
机译:暴饮暴食的动物模型通常使用压力来诱发暴饮暴食。最近的一种模型,即高脂饮食(HFD)的有限获取,表明诱导大鼠暴饮暴食不需要热量限制和压力。这项研究在小鼠中复制了该模型,探索了模型中的脂肪含量,并研究了与暴食有关的运动激活。将成年小鼠维持在限制进食(RF)计划中,即每天吃2小时或随意吃食物,然后在30分钟内每天3d / d限制吃45%HFD或84%HFD,持续6分钟总小吃会议。监测提供了84%HFD的RF动物的昼夜节律活动,并在完成6次零食训练后,连续两周连续接触45%HFD或84%HFD,以探究反弹喂养。据报道,暴饮暴食是通过每天增加摄入量来定义的,无论是否处于剥夺状态(RF或随意),提供45%HFD的小鼠,而提供84%HFD的小鼠仅在受到限制时才表现出暴饮暴食。雄性和雌性小鼠保持RF的比较,提供45%的HFD零食,表明雌性具有较高的摄入量(kcals / g-bw),而随意喂养的小鼠则没有性别差异。雌性RF小鼠的昼夜节律记录提供了84%的HFD,表明从黑暗周期的第一个小时到零食之前的一个小时,活动发生了变化,并支持提供HFD的食物相关唤醒引起改变。反弹期间,HFD含量为84%的雌性RF小鼠在第1周的摄入量最高,然后在第2周表现出明显的下降。RF动物的第1周摄入量是为了减轻体重,而在第2周则采取了类似稳态的摄入量这项调查的结果支持人类数据,即雌性更容易暴饮暴食,显示热量受限的雌性对可食用食物的有限获取会引起昼夜节律活动的变化,并且表明在该模型需要更多研究以优化暴食行为。饮食比较还表明,体内平衡和奖励机制可能对暴饮暴食有加成作用。

著录项

  • 作者

    Davis, Kristina.;

  • 作者单位

    Texas A&M University.;

  • 授予单位 Texas A&M University.;
  • 学科 Biology Neuroscience.;Psychology Physiological.
  • 学位 Ph.D.
  • 年度 2008
  • 页码 71 p.
  • 总页数 71
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-17 11:39:30

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