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Development of a New Generation of Dental Rechargeable Nanocomposites with Anti-caries Properties

机译：具有防龋性能的新一代牙科可充电纳米复合材料的开发

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摘要

Dental composites are popular for tooth cavity restorations due to their aesthetics, conservative approach, and direct-filling abilities. However, composite restorations have limited lifetime due to several limitations, including secondary caries, fracture, minimal abrasion and wear resistance and higher marginal leakage. Indeed, secondary caries is the primary reason for composite restoration failure. Besides, several studies have shown that conventional dental composites accumulate more biofilms/plaque when compared to other restorative materials. Therefore, this dissertation aims to develop a new generation of dental composites with antibacterial effects, protein-repellent activities, and remineralization properties. Recently, a rechargeable composite was developed, but this composite has no antibacterial or protein-repellent activities. In this dissertation projects, the nanoparticles of amorphous calcium and phosphate (NACP) as remineralizing agent, dimethylaminohexadecyl methacrylate (DMAHDM) as an antibacterial monomer, and 2- metha-cryloyloxyethyl phosphorylcholine (MPC) as a protein-repellent agent were incorporated into the rechargeable composite for the first time. Mechanical properties of the new nanocomposites were evaluated. The characterization of protein adsorption was measured. A human saliva microcosm biofilm model was used to determine biofilm metabolic activity, lactic acid, and colony-forming units (CFU). Calcium (Ca) and Phosphate (P) initial ion release, recharge and re-release were investigated. All rechargeable nanocomposites have good mechanical properties that were compared to those of a commercial composite. The rechargeable nanocomposites containing MPC showed the ability to reduce protein adsorption, as well as the biofilm metabolic activity, lactic acid, and CFU. The rechargeable nanocomposites containing DMAHDM showed strong antibacterial properties through the great inhibition of biofilm metabolic activity and lactic acid, and CFU. The incorporation of bioactive agents did not compromise the Ca and P initial ion release and rechargeability. The release was maintained at the same level with increasing number of recharge cycles, indicating long-term ion release. Therefore, this new generation of rechargeable nanocomposites with long-term Ca and P ion release, antibacterial and protein-repellent activities will provide the needed therapeutic effects to remineralize and strengthen the tooth structures, prolong the restoration longevity, and inhibit secondary caries.
机译：牙科复合材料因其美观，保守的方法和直接填充能力而广泛用于牙腔修复。然而，由于多种限制，复合修复体的使用寿命受到限制，包括继发龋，断裂，最小的耐磨性和耐磨性以及较高的边缘泄漏。的确，次生龋齿是复合修复失败的主要原因。此外，一些研究表明，与其他修复材料相比，常规牙科复合材料会积聚更多的生物膜/菌斑。因此，本论文旨在开发新一代的具有抗菌作用，蛋白质排斥活性和再矿化特性的牙科复合材料。最近，开发了可充电复合材料，但是这种复合材料没有抗菌或抗蛋白质活性。在本研究项目中，将无定形钙和磷酸盐（NACP）纳米颗粒作为再矿化剂，甲基丙烯酸二甲基氨基十六烷基酯（DMAHDM）作为抗菌单体和2-甲基-丙烯酰氧基乙基磷酸胆碱（MPC）作为蛋白质排斥剂。第一次合成。评估了新型纳米复合材料的机械性能。测量了蛋白质吸附的特征。使用人类唾液微观世界生物膜模型来确定生物膜代谢活性，乳酸和菌落形成单位（CFU）。研究了钙（Ca）和磷酸盐（P）的初始离子释放，再充电和再释放。与商用复合材料相比，所有可充电纳米复合材料均具有良好的机械性能。含有MPC的可充电纳米复合材料具有减少蛋白质吸附以及生物膜代谢活性，乳酸和CFU的能力。含有DMAHDM的可充电纳米复合材料通过对生物膜代谢活性和乳酸以及CFU的极大抑制，显示出强大的抗菌性能。引入生物活性剂不会损害Ca和P的初始离子释放和可充电性。随着充电循环次数的增加，释放保持在相同的水平，表明长期的离子释放。因此，这种具有长期钙和磷离子释放，抗菌和蛋白排斥活性的新一代可充电纳米复合材料将提供所需的治疗效果，以重新矿化和增强牙齿结构，延长修复寿命并抑制继发龋齿。

著录项

  • 作者

    Al Dulaijan, Yousif Ali.;

  • 作者单位

    University of Maryland, Baltimore.;

  • 授予单位 University of Maryland, Baltimore.;
  • 学科 Dentistry.
  • 学位 Ph.D.
  • 年度 2018
  • 页码 131 p.
  • 总页数 131
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 地球物理学;
  • 关键词

  • 入库时间 2022-08-17 11:53:05

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