Paracrine Regulation of Cancer Stem Cell Populations

机译：癌干细胞群体的旁分泌调节

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Stratified epithelial stem cells are responsible for skin and mucosal renewal and play an important role in homeostasis and wound healing. Lgr6 is a marker for a unique stem cell population giving rise to the different lineages in stratified epithelia. Keratin 15 expression marks a separate population of stem cells in stratified epithelia. CXC family chemokine receptors (Cxcr) are expressed as transmembrane proteins in mammalian epidermal cells. They recognize and specifically bind to chemokines of the CXC family. Recent studies have reported roles for chemokines in inflammation, tumor growth, angiogenesis, invasion, and metastasis in cancer. Selective depletion of the small K15+ stem cell fraction resulted in dramatic reduction of Lgr6+ cells and inhibition of oral tumorigenesis via senescence. Gene expression studies revealed that K15+ cancer stem cells regulate Lgr6+ cancer stem cell expansion via chemokine signaling. Genetic ablation of the chemokine receptor Cxcr2 inhibited cancer stem cell expansion and tumorigenesis via senescence. The effects of chemokines were primarily mediated by PI3K signaling, which is a candidate for targeted therapy in head and neck cancer.

机译：分层的上皮干细胞负责皮肤和粘膜的更新，并在体内平衡和伤口愈合中起重要作用。 Lgr6是独特的干细胞群体的标志物，可在分层的上皮细胞中产生不同的谱系。角蛋白15的表达标志着分层上皮细胞中干细胞的单独种群。 CXC家族趋化因子受体（Cxcr）在哺乳动物表皮细胞中表达为跨膜蛋白。它们识别并特异性结合CXC家族的趋化因子。最近的研究报道了趋化因子在癌症的炎症，肿瘤生长，血管生成，侵袭和转移中的作用。小的K15 +干细胞部分的选择性消耗导致Lgr6 +细胞显着减少，并通过衰老抑制口腔肿瘤发生。基因表达研究表明，K15 +癌症干细胞通过趋化因子信号传导调节Lgr6 +癌症干细胞的扩增。趋化因子受体Cxcr2的遗传消融通过衰老抑制癌症干细胞的扩张和肿瘤发生。趋化因子的作用主要由PI3K信号传导介导，PI3K信号传导是头颈癌靶向治疗的候选药物。

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作者
Nikolova, Gergana.;
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作者单位

University of Illinois at Chicago.;

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授予单位 University of Illinois at Chicago.;
学科 Oncology.;Cellular biology.
学位 M.S.
年度 2018
页码 65 p.
总页数 65
原文格式 PDF
正文语种 eng
中图分类遥感技术;
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入库时间 2022-08-17 11:38:51

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7. Paracrine Interaction of Cancer Stem Cell Populations Is Regulated by the Senescence-Associated Secretory Phenotype (SASP) [O] . Angelica M. Lagunas, Marybeth Francis, Nisha B. Maniar, 2019

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Paracrine Regulation of Cancer Stem Cell Populations

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