...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Allergology international: official journal of the Japanese Society of Allergology >Mannose-Binding Lectin Gene Polymorphisms in Infants with Bronchiolitis and Post-Bronchiolitis Wheezing
【24h】

Mannose-Binding Lectin Gene Polymorphisms in Infants with Bronchiolitis and Post-Bronchiolitis Wheezing

机译：毛细支气管炎和毛细支气管炎后喘息婴儿的甘露糖结合凝集素基因多态性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

ABSTRACT Background Mannose-binding lectin (MBL) encoded by the MBL2 gene, is an important component of the innate immunity. Low levels have been linked with respiratory infections and both high and low levels with allergy and asthma. The aims of the study were to evaluate the connection between polymorphisms of the MBL2 gene and viral findings, clinical characteristics and subsequent wheezing in young infants with bronchiolitis. Methods In all, 129 full-term infants hospitalized for bronchiolitis at age less than 6 months have been followed-up until the mean age of 1.5 years. The genotyping of the MBL2 gene mutations was made by pyrosequencing for a simultaneous detection of three single nucleotide polymorphisms (SNP). Results The MBL genotypes or allele frequencies had no significant associations with clinical characteristics of bronchiolitis. The 41 children with variant genotypes were more often infected by multiple viruses (21.9%, p = 0.047) than children with wild-type A/A genotypes (9.1%). In addition, more children with variant genotypes (31.7%, p = 0.016) had used corticosteroids because of post-bronchiolitis wheezing, compared to those with wild-type A/A genotypes (13.6%). No other significant associations with viral findings or post-bronchiolitis outcomes were found. Conclusions Preliminary evidence was found that the variant non-A/A genotypes may be associated with susceptibility to multiple viral infections and more severe post-bronchiolitis wheezing requiring treatment with corticosteroids.
机译：摘要背景MBL2基因编码的甘露糖结合凝集素（MBL）是先天免疫的重要组成部分。低水平与呼吸道感染有关，高和低水平与过敏和哮喘有关。该研究的目的是评估细支气管炎婴儿的MBL2基因多态性与病毒发现，临床特征和随后的喘息之间的联系。方法总共对129名年龄小于6个月的毛细支气管炎住院的足月婴儿进行了随访，直至平均年龄为1.5岁。 MBL2基因突变的基因分型是通过焦磷酸测序同时检测三个单核苷酸多态性（SNP）。结果MBL基因型或等位基因频率与毛细支气管炎的临床特征无明显关联。与具有野生型A / A基因型的儿童（9.1％）相比，具有不同基因型的41例儿童更容易被多种病毒感染（21.9％，p = 0.047）。此外，由于支气管炎后喘息的发生，与野生型A / A基因型的儿童（13.6％）相比，更多基因型变异的儿童（31.7％，p = 0.016）使用了皮质类固醇。没有发现与病毒发现或细支气管炎后结果相关的其他显着关联。结论初步证据表明，非A / A基因型变异可能与多种病毒感染和更严重的细支气管炎后喘息相关，需要用皮质类固醇治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号