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首页> 外文期刊>Saudi Journal of Biological Sciences >Effects of different components of Mao Dongqing’s total flavonoids and total saponins on transient ischemic attack (TIA) model of rats
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Effects of different components of Mao Dongqing’s total flavonoids and total saponins on transient ischemic attack (TIA) model of rats

机译：毛冬青总黄酮和总皂苷不同成分对大鼠短暂性脑缺血发作模型的影响

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Objective: To study the effects of the different components of the total flavonoids and total saponins from Mao Dongqing's active site on the rats of TIA model, determine the optimal reactive components ratio of Mao Dongqing on the rats of TIA. Methods: TIA rat model was induced by tail vein injection of tert butyl alcohol, the blank group was injected with the same amount of physiological saline, then behavioral score wasevaluated.Determination the level of glutamic acid in serum, the activity of Na+-K+-ATP enzyme, CA++-ATP enzyme and Mg++-ATP enzyme in Brain tissue, observe the changes of hippocampus in brain tissue, the comprehensive weight method was used to evaluate the efficacy of each component finally. Results: The contents of total flavonoids and total saponins in the active part of Mao Dongqing can significantly improve the pathological changes of brain tissue in rats, improve the activity of Na+-K+-ATP enzyme, Ca++-ATP enzyme and Mg++-ATP enzyme in the brain of rats, and reduce the level of glutamic acid in serum. The most significant of the contents was the ratio of 10:6. Conclusion: The different proportions of total flavonoids and total saponins in the active part of Mao Dongqing all has a better effect on the rats with TIA, and the ratio of 10:6 is the best active component for preventing and controlling TIA.
机译：目的：研究毛冬青活性部位总黄酮和总皂苷的不同成分对TIA模型大鼠的影响，确定毛冬青对TIA大鼠的最佳反应成分比。方法：用叔丁醇尾静脉注射法诱发TIA大鼠模型，空白组注射等量生理盐水，评价其行为评分。测定血清谷氨酸水平，Na + -K +-活性用脑组织中的ATP酶，CA ++-ATP酶和Mg ++-ATP酶，观察脑组织中海马的变化，最后采用综合权重法对各组分的疗效进行评价。结果：毛冬青活性部位总黄酮和总皂苷的含量可明显改善大鼠脑组织的病理变化，提高大鼠Na + -K + -ATP酶，Ca ++-ATP酶和Mg ++-ATP酶的活性。大鼠的大脑，并降低血清中的谷氨酸水平。含量中最重要的是10：6的比例。结论：毛冬青有效部位中总黄酮和总皂苷的比例不同，对TIA大鼠均有较好的作用，比例为10：6是预防和控制TIA的最佳活性成分。

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