...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biomaterials >Degradation of poly(lactide-co-glycolide) (PLGA) and poly(l-lactide) (PLLA) by electron beam radiation.
【24h】

Degradation of poly(lactide-co-glycolide) (PLGA) and poly(l-lactide) (PLLA) by electron beam radiation.

机译：电子束辐射降解聚丙交酯-乙交酯共聚物（PLGA）和聚丙交酯（PLLA）。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This paper seeks to examine the effects of electron beam (e-beam) radiation on biodegradable polymers (PLGA and PLLA), and to understand their radiation-induced degradation mechanisms. PLGA (80:20) and PLLA polymer films were e-beam irradiated at doses from 2.5 to 50Mrad and the degradation of these films were studied by measuring the changes in their molecular weights, FTIR spectra, thermal and morphological properties. The dominant effect of e-beam irradiation on both PLGA and PLLA is chain scission. Chain scission occurs first through scission of the polymer main chain, followed by hydrogen abstraction. Chain scission, though responsible for the reduction in the average molecular weight, [Formula: see text] and [Formula: see text] of both polymers, encourages crystallization in PLGA. PLLA also undergoes chain scission upon irradiation but to a lesser degree compared to PLGA. The higher crystallinity of PLLA is the key factor in its greater stability to e-beam radiation compared to PLGA. A linear relationship is also established between the decrease in molecular weight with respect to radiation dose.
机译：本文旨在研究电子束辐射对可生物降解聚合物（PLGA和PLLA）的影响，并了解其辐射诱导的降解机理。以2.5至50Mrad的剂量对PLGA（80:20）和PLLA聚合物薄膜进行电子束辐照，并通过测量其分子量，FTIR光谱，热学和形态学性质的变化研究了这些薄膜的降解。电子束照射对PLGA和PLLA的主要影响是断链。断链首先通过聚合物主链的断裂而发生，其次是氢的夺取。断链虽然导致两种聚合物的平均分子量降低，但在PLGA中却促进了结晶。 PLLA也会在辐照时发生断链，但程度要比PLGA小。与PLGA相比，PLLA的较高结晶度是其对电子束辐射更高的稳定性的关键因素。相对于辐射剂量的分子量降低之间也建立线性关系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号